Association of vitamin D deficiency with electrocardiographic markers of left atrial abnormalities.

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Abstrakt

Tytuł:: Association of vitamin D deficiency with electrocardiographic markers of left atrial abnormalities.
Autorzy:: Anees MA; Allama Iqbal Medical College, Lahore, Pakistan.
Ahmad MI; Section on Hospital Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina.
Chevli PA; Section on Hospital Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina.
Li Y; Department of Epidemiology and Prevention, Wake Forest School of Medicine, Epidemiological Cardiology Research Center (EPICARE), Winston Salem, North Carolina.
Soliman EZ; Department of Epidemiology and Prevention, Wake Forest School of Medicine, Epidemiological Cardiology Research Center (EPICARE), Winston Salem, North Carolina.; Section on Cardiology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina.
Źródło:: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc [Ann Noninvasive Electrocardiol] 2019 May; Vol. 24 (3), pp. e12626. Date of Electronic Publication: 2019 Jan 19.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Malden, MA : Wiley Periodicals, Inc.
Original Publication: Armonk, NY : Futura Pub. Co.,
MeSH Terms:: Atrial Fibrillation/*diagnostic imaging
Atrial Fibrillation/*epidemiology
Electrocardiography/*methods
Heart Atria/*abnormalities
Vitamin D Deficiency/*epidemiology
Adult ; Age Distribution ; Biomarkers ; Comorbidity ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Humans ; Linear Models ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Nutrition Surveys ; Prevalence ; Retrospective Studies ; Severity of Illness Index ; Sex Distribution ; United States/epidemiology ; Vitamin D/blood ; Vitamin D Deficiency/diagnosis
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Contributed Indexing:: Keywords: NHANES III; P wave duration; PR interval; vitamin D
Substance Nomenclature:: 0 (Biomarkers)
1406-16-2 (Vitamin D)
Entry Date(s):: Date Created: 20190120 Date Completed: 20200519 Latest Revision: 20210109
Update Code:: 20240105
PubMed Central ID:: PMC6931612
DOI:: 10.1111/anec.12626
PMID:: 30659705
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Objective: Electrocardiographic markers of left atrial (LA) abnormalities are linked to increased risk of cardiovascular disease (CVD). We examined the relationship of vitamin D deficiency with prolonged P wave duration and PR interval as markers of LA abnormalities.
Methods: This analysis included 5,894 participants (58.12 ± 12.9 years; 54.7% women; 49.8% non-Hispanic Whites) without clinical CVD from NHANES III. A multivariable logistic regression model was used to examine the association of vitamin D categories (<20 ng/ml, 20-29 ng/ml and >30 ng/ml (reference) with prolonged P wave duration (≥120 ms) and PR interval (≥200 ms).
Results: There was an incremental increase in the prevalence of prolonged P wave duration and PR interval across vitamin D categories with the highest prevalence in study participants with vitamin D levels <20 ng/ml, followed by 20-29 ng/ml and then >30 ng/ml (trend p-value < 0.0001). Vitamin D deficiency (<20 ng/ml) was associated with prolonged P wave duration (OR [95% CI]: 1.22 [1.03-1.45], p = 0.02) and prolonged PR interval (OR [95% CI]: 1.48 [1.12-1.97], p = 0.006) in multivariable logistic regression models adjusted for demographics, CVD risk factors, and other potential confounders. These associations were consistent across subgroups stratified by age, sex, and race.
Conclusions: Vitamin D deficiency is associated with an increased risk of LA abnormalities. This association elucidates an alternate pathway through which vitamin D deficiency may increase CVD risk. Whether vitamin D supplementation would improve LA abnormalities requires further investigation.
(© 2019 Wiley Periodicals, Inc.)

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