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Tytuł:
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Long-term Chronological Changes in Very Asymmetric Keratoconus.
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Autorzy:
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Koh S; Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Inoue R; Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan.; Seed Cooperation, Tokyo, Japan.
Maeda N; Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Kabata D; Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Japan.
Shintani A; Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Japan.
Jhanji V; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Klyce SD; Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY.
Maruyama K; Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Nishida K; Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
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Źródło:
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Cornea [Cornea] 2019 May; Vol. 38 (5), pp. 605-611.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: New York, N.Y. : Masson Pub. USA, c1982-
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MeSH Terms:
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Cornea/*pathology
Keratoconus/*pathology
Adolescent ; Adult ; Aged ; Astigmatism/pathology ; Corneal Pachymetry ; Corneal Topography ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; ROC Curve ; Retrospective Studies ; Tomography, Optical Coherence ; Young Adult
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Entry Date(s):
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Date Created: 20190201 Date Completed: 20190429 Latest Revision: 20190429
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Update Code:
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20240104
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DOI:
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10.1097/ICO.0000000000001890
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PMID:
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30702472
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Purpose: To investigate chronological changes in patients with very asymmetric keratoconus (KC) by Scheimpflug-based corneal tomographic evaluation.
Methods: We retrospectively reviewed the clinical records of 382 patients with KC attending a university hospital. Patients who were diagnosed with KC in one eye and forme fruste keratoconus in the other eye at the last visit and followed up with Scheimpflug-based tomographic corneal imaging were included. The anterior radius of curvature (ARC) and posterior radius of curvature (PRC) obtained at a 3.0-mm optical zone and the thinnest pachymetry reading of corneal thickness (Tmin), were used to investigate the chronological changes in tomographic parameters.
Results: Twenty-six patients aged 16 to 66 years met the inclusion criteria. The mean observation period was 6 years and 4 months. There was a significant increase in annual change in PRC with a longer follow-up period after initial examination (P = 0.011). Moreover, a greater increase in annual change in ARC was observed in patients in whom the initial examination was performed at a younger age than in those in whom it was performed at an older age (P < 0.001).
Conclusions: On the basis of tomographic evaluation, even if the measured values are almost stable and within normal limits, a long-term clinical follow-up is warranted in forme fruste keratoconus eyes. Younger patients with very asymmetric keratoconus should be monitored carefully.