-
Tytuł:
-
Ecotoxicity risk of presence of two cytostatic drugs: Bleomycin and vincristine and their binary mixture in aquatic environment.
-
Autorzy:
-
Jureczko M; Environmental Biotechnology Department, Faculty of Energy and Environmental Engineering, The Silesian University of Technology, Akademicka 2 A Str., 44-100 Gliwice, Poland. Electronic address: .
Przystaś W; Environmental Biotechnology Department, Faculty of Energy and Environmental Engineering, The Silesian University of Technology, Akademicka 2 A Str., 44-100 Gliwice, Poland; The Biotechnology Centre, The Silesian University of Technology, Krzywoustego 8 St., 44-100 Gliwice, Poland. Electronic address: .
-
Źródło:
-
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2019 May 15; Vol. 172, pp. 210-215. Date of Electronic Publication: 2019 Jan 30.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: Amsterdam, Netherlands : Elsevier
-
MeSH Terms:
-
Araceae/*drug effects
Bleomycin/*toxicity
Cytostatic Agents/*toxicity
Daphnia/*drug effects
Pseudomonas putida/*drug effects
Vincristine/*toxicity
Water Pollutants, Chemical/*toxicity
Animals ; Biodegradation, Environmental ; Bleomycin/chemistry ; Cytostatic Agents/chemistry ; Food Chain ; Fresh Water/chemistry ; Risk Assessment ; Toxicity Tests, Acute ; Vincristine/chemistry ; Wastewater/chemistry ; Water Purification
-
Contributed Indexing:
-
Keywords: Aquatic toxicology; Cytostatics; Daphnia magna; Lemna minor; Mixture toxicology; Pseudomonas putida
-
Substance Nomenclature:
-
0 (Cytostatic Agents)
0 (Waste Water)
0 (Water Pollutants, Chemical)
11056-06-7 (Bleomycin)
5J49Q6B70F (Vincristine)
-
Entry Date(s):
-
Date Created: 20190203 Date Completed: 20190411 Latest Revision: 20221207
-
Update Code:
-
20240104
-
DOI:
-
10.1016/j.ecoenv.2019.01.074
-
PMID:
-
30710771
-
Cytostatic drugs have become one of the greatest environmental threats. They occur in surface, ground and even drinking water. Their key emission sources are hospital effluents, municipal wastewater, as well as drug manufacturers and their effluents. These compounds are extremely stable in natural waters and they are not significantly removed during wastewater treatment, because they are resistant to biodegradation. The aim of this work was to establish possible negative effects of chosen cytostatics: bleomycin and vincristine on the three trophic levels of surface waters. A single agent acute toxicity test was conducted on representatives of the producer - an aquatic freshwater plant Lemna minor, the consumer - crustaceans Daphnia magna, and the decomposer - bacteria Pseudomonas putida. Binary mixture tests were performed according to the Concentration Addition, Response Additivity, and Independent Action models. Both substances had a different effect on the tested organisms; bleomycin could be classified as a very toxic, while vincristine as a toxic water pollutant. Half maximal effective concentration (EC50) values designed in the presented single agent acute toxicity studies are < 10 mg/L in all the tests with bleomycin as well as vincristine conducted on L. minor. In tests with vincristine performed on D. magna and P. putida EC50 > 100 mg/L. The highest toxicity is demonstrated by bleomycin towards the aquatic freshwater plant (EC50 = 0.2 mg/L). The binary mixture of the tested chemicals showed antagonistic effects of environmental concern.
(Copyright © 2019 Elsevier Inc. All rights reserved.)