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Tytuł pozycji:

Rabies post-exposure prophylaxis initiation and adherence among patients in Vietnam, 2014-2016.

Tytuł:
Rabies post-exposure prophylaxis initiation and adherence among patients in Vietnam, 2014-2016.
Autorzy:
Tran CH; Epidemic Intelligence Service, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, United States; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, United States. Electronic address: .
Afriyie DO; U.S. Centers for Disease Control and Prevention Country Office in Vietnam, 2 Ngo Quyen, Hanoi, Viet Nam.
Pham TN; National Institute of Hygiene and Epidemiology, Ministry of Health, 1 Yersin Street, Hanoi, Viet Nam.
Otsu S; World Health Organization, Representative Office for Vietnam, 304 Kim Ma Street, Hanoi, Viet Nam.
Urabe M; World Health Organization, Representative Office for Vietnam, 304 Kim Ma Street, Hanoi, Viet Nam.
Dang AD; National Institute of Hygiene and Epidemiology, Ministry of Health, 1 Yersin Street, Hanoi, Viet Nam.
Tran HGT; International Cooperation Department, Ministry of Health, 138A Giang Vo, Hanoi, Viet Nam.
Nguyen HV; National Institute of Hygiene and Epidemiology, Ministry of Health, 1 Yersin Street, Hanoi, Viet Nam.
Le HT; Hanoi Medical University, No 1 Ton That Tung, Hanoi, Viet Nam.
Nguyen HTT; National Institute of Hygiene and Epidemiology, Ministry of Health, 1 Yersin Street, Hanoi, Viet Nam.
Źródło:
Vaccine [Vaccine] 2019 Oct 03; Vol. 37 Suppl 1, pp. A54-A63. Date of Electronic Publication: 2019 Feb 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: Amsterdam, The Netherlands : Elsevier Science
Original Publication: [Guildford, Surrey, UK] : Butterworths, [c1983-
MeSH Terms:
Medication Adherence/*statistics & numerical data
Post-Exposure Prophylaxis/*methods
Post-Exposure Prophylaxis/*statistics & numerical data
Rabies/*prevention & control
Cost of Illness ; Humans ; Immunologic Factors/administration & dosage ; Patient Acceptance of Health Care/statistics & numerical data ; Rabies/epidemiology ; Rabies/mortality ; Rabies Vaccines/administration & dosage ; Survival Analysis ; Vietnam/epidemiology
Grant Information:
001 International WHO_ World Health Organization
Contributed Indexing:
Keywords: Canine; Human; Immunoglobulin; Post-exposure prophylaxis; Rabies; Vaccine
Substance Nomenclature:
0 (Immunologic Factors)
0 (Rabies Vaccines)
Entry Date(s):
Date Created: 20190207 Date Completed: 20200415 Latest Revision: 20220129
Update Code:
20240105
DOI:
10.1016/j.vaccine.2019.01.030
PMID:
30723063
Czasopismo naukowe
Background: Adhering to post-exposure prophylaxis (PEP): wound treatment, vaccine, and rabies immunoglobulin (RIG) is a crucial step in preventing rabies mortality. When PEP is widely available, a lack of adherence to the recommended treatment guidelines can also lead to death. Our objective was to understand characteristics associated with adherence to the vaccine regimen and RIG in Vietnam.
Methods: We obtained individual-level data on PEP adherence from registries at 10 sites located in five provinces. From these registries, we extracted epidemiologic characteristics of patients including the timing of PEP initiation and completion. We used descriptive analyses and logistic regression to examine patient characteristics associated with initiation and completion of RIG and vaccine. Based on reported rabies mortality, the government defined provincial rabies burden as medium-burden (<5 and >2 deaths) and high-burden (≥5 deaths).
Results: During 2014-2016, 15,646 patients received PEP in our study. Among 14,296 vaccinated patients, only 41.4% (5847) completed their five-dose intramuscular (IM) injections and 81.6% (133) of patients completed their eight-dose intradermal (ID) injections. Approximately 26% of patients received RIG. Patient characteristics associated with vaccine completion were females (44%), <15 years of age (44%), category 1 exposure (68%, bite location on leg (46%), bite from bat (56%), bite from a healthy animal (45%), high-burden province (86%), and district preventive center (49%). Disparities were revealed among provinces, with high-burden provinces having highest (86%) and lowest (7%) vaccine completion rates.
Conclusions and Relevance: Vietnam has made tremendous progress towards reducing the burden of rabies. However, despite the wide availability of PEP, we found relatively low rates of vaccine completion. Our findings suggest provider training and patient education is needed to ensure appropriate treatment is completed. Moreover, our data suggest changes to information reported through the national surveillance system for monitoring good clinical practice for rabies prevention and control.
(Published by Elsevier Ltd.)

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