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Tytuł pozycji:

[Methodological aspects of interpretation of thyroid-stimulating hormone reference intervals in the Northwest region megapolis hospital.]

Tytuł :
[Methodological aspects of interpretation of thyroid-stimulating hormone reference intervals in the Northwest region megapolis hospital.]
Autorzy :
Volkova AR; FSBEI HE «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of Russian Federation, 197022, Saint Petersburg, Russia.
Dygun OD; FSBEI HE «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of Russian Federation, 197022, Saint Petersburg, Russia.
Katysheva NS; FSBEI HE «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of Russian Federation, 197022, Saint Petersburg, Russia.
Bondarenko VL; FSBEI HE «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of Russian Federation, 197022, Saint Petersburg, Russia.
Maltseva MN; FSBEI HE «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of Russian Federation, 197022, Saint Petersburg, Russia.
Belyakova LA; FSBEI HE «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of Russian Federation, 197022, Saint Petersburg, Russia.
Emanuel VL; FSBEI HE «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of Russian Federation, 197022, Saint Petersburg, Russia.
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Źródło :
Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2018; Vol. 63 (9), pp. 538-542.
Typ publikacji :
Journal Article
Język :
Russian
Imprint Name(s) :
Original Publication: Moskva : "Meditsina", 1992-
MeSH Terms :
Hypothyroidism/*diagnosis
Thyrotropin/*blood
Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Reference Values ; Russia ; Thyroid Function Tests
Contributed Indexing :
Keywords: subclinical hypothyroidism; thyroid gland; thyroid-stimulating hormone
Substance Nomenclature :
9002-71-5 (Thyrotropin)
Entry Date(s) :
Date Created: 20190209 Date Completed: 20190722 Latest Revision: 20190816
Update Code :
20210210
DOI :
10.18821/0869-2084-2018-63-9-538-542
PMID :
30735318
Czasopismo naukowe
The prevalence of subclinical hypothyroidism (SH) is large and according to various studies is from 3 to 21%. In the Russian Federation to date, there are no major epidemiological studies assessing the functional state of the thyroid gland. It seems relevant to study the TSH level in patients who turned to the clinical units of a large hospital in the North-West region to determine the prevalence of thyroid dysfunction in patients of different sex and age. 5,303 patients were examined, who applied to the I.P. Pavlov SPbSMU clinics for 2017. In all patients the level of TSH and free T4 was determined. SH was considered to increase the level of TSH more than 4.0 mIU/l at a normal level of free T4. Patients were divided into groups by age and TSH level in accordance with existing recommendations. Among the examined patients were 29.26% of men and 70.73% of women. The mean age was 55.08 ± 17.07 years. The TSH level had an abnormal distribution and averaged 2.77 mIU/l (TSH median 1.73 mIU/l). In women the level of TSH was significantly higher in all studied groups of patients (p = 0.0001). Among women, significant differences in the level of TSH between the elderly and young patients (p = 0.015) were found. The incidence of SH in the total group of patients was 10.1%. In the men surveyed, the incidence of SH was 7.3%, and in the female group - 11.3%. In the elderly patients, the incidence of subclinical hypothyroidism in women was 2 times higher than that of men. In most cases (77.4%) in patients with SH, the TSH level was in the range of 4.0-6.9 mIU / L. The clinical significance of minimal thyroid insufficiency requires further study.

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