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Tytuł:
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Extraction and Separation of Eight Ginsenosides from Flower Buds of Panax Ginseng Using Aqueous Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with an Aqueous Biphasic System.
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Autorzy:
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Liang Q; College of Life Sciences, Jilin University, Changchun 130012, China. .
Zhang J; College of Biological and Agricultural Engineering, Jilin University, Changchun 130022, China. .
Su X; College of Chemistry, Jilin University, Changchun 130012, China. .
Meng Q; Plusone Native Co., Ltd., Changchun 130012, China. .
Dou J; College of Biological and Agricultural Engineering, Jilin University, Changchun 130022, China. .
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Źródło:
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Molecules (Basel, Switzerland) [Molecules] 2019 Feb 21; Vol. 24 (4). Date of Electronic Publication: 2019 Feb 21.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Basel, Switzerland : MDPI, c1995-
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MeSH Terms:
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Ginsenosides/*isolation & purification
Ionic Liquids/*chemistry
Liquid-Liquid Extraction/*methods
Panax/*chemistry
Solvents/*chemistry
Water/*chemistry
Factor Analysis, Statistical ; Flowers/chemistry ; Ginsenosides/classification ; Humans ; Hydrogen-Ion Concentration ; Plant Extracts/chemistry ; Plants, Medicinal ; Sonication ; Temperature ; Time Factors
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References:
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Contributed Indexing:
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Keywords: aqueous biphasic system; ginseng flower buds; ginsenosides; ionic liquids; response surface methodology; separation; ultrasonic-assisted extraction
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Substance Nomenclature:
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0 (Ginsenosides)
0 (Ionic Liquids)
0 (Plant Extracts)
0 (Solvents)
059QF0KO0R (Water)
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Entry Date(s):
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Date Created: 20190224 Date Completed: 20190610 Latest Revision: 20200225
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Update Code:
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20240104
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PubMed Central ID:
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PMC6413155
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DOI:
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10.3390/molecules24040778
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PMID:
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30795582
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Ionic liquids (ILs) are recognized as a possible replacement of traditional organic solvents, and ILs have been widely applied to extract various compounds. The present work aims to extract ginsenosides from Panax ginseng flower buds using aqueous ionic liquid based ultrasonic assisted extraction (IL-UAE). The extraction yields of 1-alkyl-3-methylimidazolium ionic liquids with different anions and alkyl chains were evaluated. The extraction parameters of eight ginsenosides were optimized by utilizing response surface methodology (RSM). The model demonstrated that a high yield of total ginsenosides could be obtained using IL-UAE, and the optimum extraction parameters were 0.23 M [C₄mim][BF₄], ultrasonic time of 23 min, temperature of extraction set to 30 °C, and liquid-solid ratio of 31:1. After that, an aqueous biphasic system (ABS) was used to separate ginsenosides further. The nature and concentration of salt, as well as the value of pH in ionic liquid were evaluated, and the optimal conditions (6.0 mL IL extract, 3 g NaH₂PO₄, and pH 5.0) were obtained. The preconcentration factor was 2.58, and extraction efficiency reached 64.53%. The results indicate that as a simple and efficient method, an IL-UAE-ABS can be considered as a promising method for extracting and separating the natural active compounds from medicinal herbs.
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