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Tytuł:
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Assessment of liver cirrhosis for patients with Child's A classification before hepatectomy using dynamic contrast-enhanced MRI.
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Autorzy:
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Liao YS; Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Yunlin, Taiwan; Department of Nursing, Chang Gung University of Science and Technology, Chiayi, Taiwan; Department of Chemistry and Biochemistry, National Chung Cheng University, Chiayi, Taiwan.
Lee LW; Department of Nursing, Chang Gung University of Science and Technology, Chiayi, Taiwan; Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Yang PH; Department of Chemistry and Biochemistry, National Chung Cheng University, Chiayi, Taiwan.
Kuo LM; Department of General Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Kuan LY; Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Tseng WI; Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan.
Hwang DW; Department of Chemistry and Biochemistry, National Chung Cheng University, Chiayi, Taiwan; Center for NanoBiodetection, National Chung Cheng University, Chiayi, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Electronic address: .
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Źródło:
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Clinical radiology [Clin Radiol] 2019 May; Vol. 74 (5), pp. 407.e11-407.e17. Date of Electronic Publication: 2019 Feb 21.
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Typ publikacji:
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Evaluation Study; Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Oxford : Blackwell Scientific Publications Ltd
Original Publication: Edinburgh, Livingstone.
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MeSH Terms:
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Hepatectomy*
Liver Cirrhosis/*pathology
Adult ; Aged ; Aged, 80 and over ; Area Under Curve ; Contrast Media ; Feasibility Studies ; Female ; Humans ; Liver Cirrhosis/surgery ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Observer Variation ; Preoperative Care/methods
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Substance Nomenclature:
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0 (Contrast Media)
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Entry Date(s):
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Date Created: 20190226 Date Completed: 20200224 Latest Revision: 20200224
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Update Code:
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20240104
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DOI:
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10.1016/j.crad.2019.01.017
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PMID:
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30799098
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Aim: To determine the feasibility of semi-quantitative haemodynamic parameters derived from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) to assess liver fibrosis.
Materials and Methods: Seventy-five patients with Child's A classification (males/females=24/51; average age, 58 years; range, 30-80 years) received DCE-MRI 3 days prior to hepatectomy. Semi-quantitative haemodynamic parameters, including the wash-in slope, wash-out slope, and time-to-peak, were calculated from DCE-MRI data. Liver fibrosis of the resected non-tumour liver was graded pathologically from F0 (no fibrosis) to F6 (cirrhosis) in the regions corresponding to those assessed by DCE-MRI.
Results: The wash-out slope showed higher interobserver and intra-observer reliabilities than the wash-in slope and time-to-peak. There was a significant positive correlation between the wash-out slope and pathological grade of fibrosis (Spearman's correlation coefficient: r=0.5331, p<0.0001). The area under the receiver operating characteristic curve was 0.8066 when using the wash-out slope to differentiate cirrhosis (grade F6) from non-cirrhosis (grades F0-5). Using the cut-off point that maximised specificity, the sensitivity was 62.07%, specificity was 91.30%, positive predictive value was 81.81%, negative predictive value was 79.25%, and accuracy was 80%.
Conclusions: The wash-out slope derived from DCE-MRI might be potentially useful in assessing liver cirrhosis in patients with Child's A classification before hepatectomy.
(Copyright © 2019. Published by Elsevier Ltd.)
