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Tytuł:
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Ultra-small micelles based on polyoxyl 15 hydroxystearate for ocular delivery of myricetin: optimization, in vitro, and in vivo evaluation.
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Autorzy:
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Hou Y; a Department of Pharmacy, College of Chemical Engineering , Qingdao University of Science and Technology , Qingdao , China.
Zhang F; a Department of Pharmacy, College of Chemical Engineering , Qingdao University of Science and Technology , Qingdao , China.
Lan J; b Qingdao Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences , Qingdao , China.
Sun F; a Department of Pharmacy, College of Chemical Engineering , Qingdao University of Science and Technology , Qingdao , China.
Li J; b Qingdao Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences , Qingdao , China.
Li M; a Department of Pharmacy, College of Chemical Engineering , Qingdao University of Science and Technology , Qingdao , China.; c Qingdao Women and Children's Hospital, Pharmacy Intravenous Admixture Services , Qingdao , China.
Song K; a Department of Pharmacy, College of Chemical Engineering , Qingdao University of Science and Technology , Qingdao , China.
Wu X; a Department of Pharmacy, College of Chemical Engineering , Qingdao University of Science and Technology , Qingdao , China.
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Źródło:
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Drug delivery [Drug Deliv] 2019 Dec; Vol. 26 (1), pp. 158-167.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 2015->: Abingdon, Oxford : Taylor & Francis
Original Publication: Orlando, FL : Academic Press, c1993-
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MeSH Terms:
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Administration, Ophthalmic*
Micelles*
Drug Delivery Systems/*methods
Flavonoids/*administration & dosage
Administration, Topical ; Animals ; Cornea/drug effects ; Cornea/metabolism ; Drug Delivery Systems/standards ; Drug Evaluation, Preclinical/methods ; Drug Evaluation, Preclinical/standards ; Flavonoids/chemistry ; Flavonoids/metabolism ; Mice ; Ophthalmic Solutions/administration & dosage ; Ophthalmic Solutions/chemistry ; Ophthalmic Solutions/metabolism ; Permeability/drug effects ; Random Allocation
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References:
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Curr Eye Res. 1999 Sep;19(3):234-40. (PMID: 10487961)
Ophthalmic Res. 2002 Sep-Oct;34(5):319-23. (PMID: 12381895)
Pharmazie. 2002 Dec;57(12):820-4. (PMID: 12561244)
Exp Eye Res. 2007 Jul;85(1):154-65. (PMID: 17544396)
J Agric Food Chem. 2009 Mar 11;57(5):1768-74. (PMID: 19199445)
Langmuir. 2009 May 19;25(10):5773-7. (PMID: 19320475)
J Ocul Pharmacol Ther. 2011 Oct;27(5):437-44. (PMID: 21714635)
Ther Deliv. 2011 Jul;2(7):949-56. (PMID: 22833905)
Pharm Res. 2012 Dec;29(12):3512-25. (PMID: 22961588)
Iran J Public Health. 2012;41(6):72-9. (PMID: 23113196)
Pharmazie. 2014 Jan;69(1):19-26. (PMID: 24601218)
Cornea. 2014 May;33(5):521-6. (PMID: 24619166)
Mol Vis. 2014 Mar 03;20:242-58. (PMID: 24623967)
J Phys Chem B. 2014 Aug 7;118(31):9515-23. (PMID: 25029529)
Carbohydr Polym. 2015 Mar 6;117:169-76. (PMID: 25498622)
Nanomedicine. 2015 Apr;11(3):521-30. (PMID: 25659643)
Ther Deliv. 2015;6(12):1365-76. (PMID: 26652282)
J Agric Food Chem. 2016 Aug 17;64(32):6286-94. (PMID: 27455843)
Int J Pharm. 2016 Oct 15;512(1):186-193. (PMID: 27567930)
Int J Nanomedicine. 2016 Sep 08;11:4563-4571. (PMID: 27660448)
J Control Release. 2017 Feb 28;248:96-116. (PMID: 28087407)
Int J Food Sci Nutr. 2017 Sep;68(6):704-711. (PMID: 28114854)
J Control Release. 2017 Dec 28;268:19-39. (PMID: 28756272)
Int J Pharm. 2018 Apr 25;541(1-2):72-80. (PMID: 29458206)
Colloids Surf B Biointerfaces. 2018 Apr 27;169:20-29. (PMID: 29747027)
Invest Ophthalmol Vis Sci. 2018 Jul 2;59(8):3286-3293. (PMID: 29971448)
Retrovirology. 2018 Jul 16;15(1):49. (PMID: 30012153)
Curr Eye Res. 2019 Jan;44(1):25-29. (PMID: 30196728)
J Food Sci Technol. 2018 Oct;55(10):3872-3880. (PMID: 30228385)
Int J Pharm. 2018 Dec 1;552(1-2):265-276. (PMID: 30291959)
Int J Pharm. 2018 Dec 20;553(1-2):21-28. (PMID: 30316795)
Anal Biochem. 1996 Jul 15;239(1):70-6. (PMID: 8660627)
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Contributed Indexing:
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Keywords: Myricetin; micelle; ocular drug delivery; polyoxyl 15 hydroxystearate; stability
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Substance Nomenclature:
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0 (Flavonoids)
0 (Micelles)
0 (Ophthalmic Solutions)
76XC01FTOJ (myricetin)
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Entry Date(s):
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Date Created: 20190302 Date Completed: 20190614 Latest Revision: 20200225
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Update Code:
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20240105
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PubMed Central ID:
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PMC6407586
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DOI:
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10.1080/10717544.2019.1568624
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PMID:
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30822157
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The aim was to develop a nanocarrier based on polyoxyl 15 hydroxystearate (Kolliphor® HS15, HS15) micelles for the solubility, stability, and ocular delivery of myricetin (Myr). An optimized ratio of HS15 and Myr was prepared to fabricate HS15-Myr micelle ophthalmic solution. Myr-encapsulating HS15 micelles (HS15-Myr micelles) were subjected to physicochemical characterizations. The chemical stability of Myr in HS15 micelles and storage stability of HS15-Myr micelle ophthalmic solutions were evaluated. In vitro parallel artificial membrane permeability assay and antioxidant activity of Myr in HS15 micelles were also measured. In vivo ocular tolerance, corneal permeation, and anti-inflammatory efficacy studies were conducted following ocular topical administration. HS15-Myr micelles were successfully prepared and presented transparent appearance with high encapsulation (96.12 ± 0.31%), ultra-small micelle size (a mean diameter of 12.17 ± 0.73 nm), uniform size distribution (polydispersity index [PDI] = 0.137 ± 0.013), and negative surface charge (- [4.28 ± 0.42] mV). Myr in HS15 micelle solution demonstrated higher aqueous stability than the free Myr solution among the accepted pH range for eyedrops. HS15-Myr micelle ophthalmic solution demonstrated high storage stability at 4 °C and 25 °C. HS15 micelles could significantly improve in vitro antioxidant activity and faster membrane permeation of Myr. No irritations or corneal damage were revealed in rabbit eyes after ocular administration of HS15-Myr micelle solution. In vivo corneal permeation study demonstrated that HS15-Myr micelles could penetrate the cornea efficiently in mouse eyes. Further, HS15-Myr micelles also demonstrated significant in vivo anti-inflammatory activity. It can be concluded that HS15 micelles are a potential ophthalmic delivery nanocarrier for poorly soluble drugs such as Myr.
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