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Tytuł:
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Clinical usefulness of brain-derived neurotrophic factor and visinin-like protein-1 in early diagnostic tests for acute stroke.
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Autorzy:
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Algin A; Department of Emergency Medicine, Health of Sciences Umraniye Training and Research Hospital, Istanbul, Turkey. Electronic address: .
Erdogan MO; Department of Emergency Medicine, Bahcesehir University, Istanbul, Turkey.
Aydin I; Department of Emergency Medicine, Adiyaman University Training and Research Hospital, Adiyaman, Turkey.
Poyraz MK; Department of Emergency Medicine, Adiyaman University Training and Research Hospital, Adiyaman, Turkey.
Sirik M; Department of Radiology, Adiyaman University Training and Research Hospital, Adiyaman, Turkey.
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Źródło:
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The American journal of emergency medicine [Am J Emerg Med] 2019 Nov; Vol. 37 (11), pp. 2051-2054. Date of Electronic Publication: 2019 Feb 25.
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Typ publikacji:
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Clinical Trial; Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 1983- : Philadelphia, PA : W B Saunders
Original Publication: [Philadelphia, PA. : Centrum Philadelphia, c1983]-
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MeSH Terms:
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Brain-Derived Neurotrophic Factor/*blood
Neurocalcin/*blood
Stroke/*diagnosis
Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Case-Control Studies ; Early Diagnosis ; Emergency Service, Hospital ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; ROC Curve ; Stroke/blood ; Stroke/mortality
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Contributed Indexing:
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Keywords: Acute stroke; BDNF; Emergency department; VILIP-1
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Substance Nomenclature:
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0 (Biomarkers)
0 (Brain-Derived Neurotrophic Factor)
0 (Neurocalcin)
0 (VSNL1 protein, human)
7171WSG8A2 (BDNF protein, human)
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Entry Date(s):
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Date Created: 20190304 Date Completed: 20200325 Latest Revision: 20200325
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Update Code:
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20240105
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DOI:
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10.1016/j.ajem.2019.02.037
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PMID:
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30826210
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Objectives: Lack of a rapid biochemical test for acute stroke is a limitation in the diagnosis and management of acute stroke. The aim of this study is to evaluate the efficacy of BDNF and VILIP-1 as diagnostic markers in acute ischemic stroke and as predictors of mortality.
Methods: The study included 75 patients with acute ischemic stroke older than 18 years. During the same period, 28 normal controls were recruited from the hospital ED. Blood samples were collected from all patients at admission to determine the levels of VILIP-1 and BDNF.
Results: The mean VILIP-1 levels in the study and control groups were 0.547 ± 0.081 and 0.515 ± 0.035 ng/mL, respectively, and the difference was not significant (p = 0.071). The mean BDNF levels in the study and control groups were 3.89 ± 2.05 ng/mL and 14.9 ± 4.7 ng/mL, respectively, and the level was significantly (p < 0.0001) lower in the stroke patients.
Conclusion: The BDNF level showed a significant ability to discriminate stroke and control patients but did not predict mortality. The VILIP-1 level showed insignificant ability to discriminate stroke patients and again did not predict mortality.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
