Diagnosis of subclinical extramammary Paget's disease with a combination of noninvasive photodynamic diagnosis and reflectance confocal microscopy.

Szczegóły
Abstrakt

Tytuł:: Diagnosis of subclinical extramammary Paget's disease with a combination of noninvasive photodynamic diagnosis and reflectance confocal microscopy.
Autorzy:: Huang L; Department of Dermatologic Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Wang Y; Department of Dermatologic Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Wu M; Department of Dermatology, The Fifth People's Hospital of Suzhou, The Affiliated Hospital of Infectious Diseases of Soochow University, Suzhou, China.
Zhao J; Department of Dermatology, Changshu No. 1 People's Hospital, Changshu, Jiangsu Province, China.
Zhang W; Department of Dermatologic Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Zhao L; Department of Dermatologic Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Mo X; Department of Dermatology, The Fifth People's Hospital of Suzhou, The Affiliated Hospital of Infectious Diseases of Soochow University, Suzhou, China.
Fang F; Department of Dermatologic Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Źródło:: Indian journal of dermatology, venereology and leprology [Indian J Dermatol Venereol Leprol] 2021 May-Jun; Vol. 87 (3), pp. 371-374.
Typ publikacji:: Case Reports
Język:: English
Imprint Name(s):: Publication: 2021- : Pittsford, NY : Scientific Scholar on behalf of Indian Association of Dermatologists, Venereologists & Leprologists
Original Publication: Vellore, Indian Assn. of Dermatologists, Venereologists and Leprologists.
MeSH Terms:: Light*
Microscopy, Confocal*
Genital Neoplasms, Male/*diagnosis
Paget Disease, Extramammary/*diagnosis
Skin Neoplasms/*diagnosis
Aminolevulinic Acid ; Humans ; Male ; Middle Aged ; Photosensitizing Agents
References:: Parker LP, Parker JR, Bodurka Bevers D, Deavers M, Bevers MW, Shen Gunther J, et al. Paget's disease of the vulva: Pathology, pattern of involvement, and prognosis. Gynecol Oncol. 2000; 77:183 -9. (PMID: 10.1006/gyno.2000.574110739709)
Luyten A, Sörgel P, Clad A, Gieseking F, Maass Poppenhusen K, Lellé RJ, et al. Treatment of extramammary Paget disease of the vulva with imiquimod: A retrospective, multicenter study by the German colposcopy network. J Am Acad Dermatol. 2014; 70:644 -50. (PMID: 10.1016/j.jaad.2013.12.00824433876)
Hendi A, Brodland DG, Zitelli JA,. Extramammary Paget's disease: Surgical treatment with Mohs micrographic surgery. J Am Acad Dermatol. 2004; 51:767 -73. (PMID: 10.1016/j.jaad.2004.07.00415523356)
Jing W, Juan X, Li X, Jiayuan C, Qin H, Qing L, et al. Complete remission of two patients with recurrent and wide spread extramammary Paget disease obtained from 5 aminolevulinic acid based photodynamic therapy and imiquimod combination treatment. Photodiagnosis Photodyn Ther2014;.11:434 -40. (PMID: 10.1016/j.pdpdt.2014.03.00624657920)
Guitera P, Scolyer RA, Gill M, Akita H, Arima M, Yokoyama Y, et al. Reflectance confocal microscopy for diagnosis of mammary and extramammary Paget's disease. J Eur Acad Dermatol Venereol. 2013; 27: e24 -9. (PMID: 10.1111/j.1468-3083.2011.04423.x22211938)
Yélamos O, Hibler BP, Cordova M, Hollmann TJ, Kose K, Marchetti MA, et al. Handheld reflectance confocal microscopy for the detection of recurrent extramammary Paget disease. JAMA Dermatol. 2017; 153: 689 -93. (PMID: 10.1001/jamadermatol.2017.061928492924)
Pan ZY, Liang J, Zhang QA, Lin JR, Zheng ZZ,. In vivo reflectance confocal microscopy of extramammary Paget disease: Diagnostic evaluation and surgical management. J Am Acad Dermatol. 2012; 66: e47 -53. (PMID: 10.1016/j.jaad.2010.09.72221620517)
Mun JH, Park SM, Kim GW, Song M, Kim HS, Ko HC, et al. Clinical and dermoscopic characteristics of extramammary Paget disease: A study of 35 cases. Br J Dermatol. 2016; 174:1104 -7. (PMID: 10.1111/bjd.1430026581826)
Chuh A, Zawar V, Fölster Holst R,. Dermoscope guided lesional biopsy to diagnose EMA+ CK7+ CK20+ extramammary Paget's disease with an extensive lesion. J Eur Acad Dermatol Venereol. 2018; 32: e92 -4. (PMID: 10.1111/jdv.1453928846155)
Contributed Indexing:: Keywords: Extramammary; Paget’s disease; photodynamic diagnosis; reflectance confocal microscopy
Substance Nomenclature:: 0 (Photosensitizing Agents)
88755TAZ87 (Aminolevulinic Acid)
Entry Date(s):: Date Created: 20190305 Date Completed: 20211110 Latest Revision: 20211110
Update Code:: 20240105
DOI:: 10.4103/ijdvl.IJDVL_895_17
PMID:: 30829297
: Raport

Pełny tekst

Extramammary Paget's disease is a rare skin malignancy, and its diagnosis requires invasive biopsy and histopathological examination. Surgery is the standard treatment for extramammary Paget's disease patients; however, as incision boundaries and the depth of tumor cell infiltration are often unclear, the postoperative recurrence rate is high. We present a case in which we used photodynamic diagnosis in combination with reflectance confocal microscopy before surgery to detect an extramammary Paget's disease lesion that was located 3 cm away from the classical lesion. This secondary lesion exhibited a subclinical presentation, and it was eventually confirmed as an extramammary Paget's disease lesion by pathological examination. During detection using our technique, we delineated the boundaries of the extramammary Paget's disease lesion as a guide for surgical excision. The findings of our case demonstrate that photodynamic diagnosis combined with reflectance confocal microscopy can be used for the noninvasive diagnosis of subclinical extramammary Paget's disease and may be used to guide strategies for planning treatment and preventing relapse.

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