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Tytuł pozycji:

New fluoroquinolone compounds with endo-nortropine derivatives at C-7 position show antibacterial activity against fluoroquinolone-resistant strains of Staphylococcus aureus.

Tytuł:
New fluoroquinolone compounds with endo-nortropine derivatives at C-7 position show antibacterial activity against fluoroquinolone-resistant strains of Staphylococcus aureus.
Autorzy:
Salunke RA; School of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala, India.; Saurav Chemicals Limited, Derabassi- Mohali, India.
Shukla M; CDRI - Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, India.
Kaul G; CDRI - Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, India.
Bansal BR; Saurav Chemicals Limited, Derabassi- Mohali, India.
Chopra S; CDRI - Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, India.
Chhibber M; School of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala, India.
Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2019 Sep; Vol. 94 (3), pp. 1626-1633. Date of Electronic Publication: 2019 Jul 10.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Oxford : Wiley-Blackwell, 2006-
MeSH Terms:
Anti-Bacterial Agents/*chemical synthesis
Bacterial Infections/*drug therapy
Fluoroquinolones/*chemical synthesis
Nortropanes/*chemistry
Amines/chemistry ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Drug Evaluation, Preclinical ; Drug Resistance, Bacterial ; Esters/chemistry ; Fluoroquinolones/pharmacology ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship
References:
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Contributed Indexing:
Keywords: N-methylpiperazine; levofloxacin; morpholine; nalidixic acid; piperidine
Substance Nomenclature:
0 (Amines)
0 (Anti-Bacterial Agents)
0 (Esters)
0 (Fluoroquinolones)
0 (Nortropanes)
Entry Date(s):
Date Created: 20190313 Date Completed: 20200915 Latest Revision: 20200915
Update Code:
20240105
DOI:
10.1111/cbdd.13513
PMID:
30860312
Czasopismo naukowe
A series of new fluoroquinolone analogs (3-18) were prepared, in three steps, by substituting chloro esters and esters with cyclic amines on the C-7 endo-nortropine derivatives of difluoroquinolone acid. All the synthesized compounds displayed good MIC against the Staphylococcus aureus when initially screened for Escherichia coli, S. aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa. The molecules were further evaluated for their antibacterial activity against fluoroquinolone-resistant strains of S. aureus and for cytotoxic assay. Based on the results, five of the sixteen compounds displayed the potential to be developed further for treatment against fluoroquinolone-resistant strains of S. aureus.
(© 2019 John Wiley & Sons A/S.)
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