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Tytuł:
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Toxicological evaluation of carcinogenicity of the pyrethroid imiprothrin in rats and mice.
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Autorzy:
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Yamada T; Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan. Electronic address: .
Asano H; Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan.
Miyata K; Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka, 554-8558, Japan.
Rhomberg LR; Gradient, 20 University Road, Cambridge, MA, 02138, USA.
Haseman JK; J.K. Haseman Consulting, Raleigh, NC, USA.
Greaves P; Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK.
Greim H; Technical University of Munich, Munich, Germany.
Berry C; Queen Mary University of London, Mile End Rd, London, E1 4NS, UK.
Cohen SM; Havlik-Wall Professor of Oncology, Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135, Omaha, NE, 68198-3135, USA.
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Źródło:
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Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Jul; Vol. 105, pp. 1-14. Date of Electronic Publication: 2019 Mar 21.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: <2003>- : Amsterdam : Elsevier
Original Publication: New York : Academic Press, [c1981-
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MeSH Terms:
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Adenocarcinoma/*chemically induced
Adenoma/*chemically induced
Lung Neoplasms/*chemically induced
Pesticides/*toxicity
Pyrethrins/*toxicity
Adenocarcinoma/epidemiology ; Adenoma/epidemiology ; Animals ; Carcinogenicity Tests/methods ; Diet ; Dose-Response Relationship, Drug ; Female ; Lung Neoplasms/epidemiology ; Male ; Maximum Tolerated Dose ; Mice ; Mice, Inbred ICR ; Pyrethrins/administration & dosage ; Rats ; Rats, Sprague-Dawley ; Sex Factors ; Species Specificity
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Contributed Indexing:
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Keywords: Carcinogenicity; Imiprothrin; Long-term bioassays; Lung tumors; Maximum tolerated dose; Mouse; Pyrethroids; Statistical analysis; Step section; Systemic toxicity
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Substance Nomenclature:
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0 (Pesticides)
0 (Pyrethrins)
73OFA861WY (imiprothrin)
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Entry Date(s):
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Date Created: 20190326 Date Completed: 20190708 Latest Revision: 20190820
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Update Code:
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20240105
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DOI:
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10.1016/j.yrtph.2019.03.012
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PMID:
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30905765
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The carcinogenic potential of a non-genotoxic pyrethroid imiprothrin was examined in rats and mice. There was no carcinogenicity in rats up to a maximum dose of 5000 ppm of the diet. There was a higher (p = 0.03) incidence of lung adenocarcinomas at 7000 ppm in males, and females showed an increasing (p < 0.01) trend in the incidence of lung adenomas and combined lung adenoma/adenocarcinomas. Additional step sections of lung demonstrated no significant increases in any tumor at p < 0.05, although an increasing trend with dose was observed among females. We argue that, the 7000 ppm dose exceeded the Maximum Tolerated Dose (MTD) for both sexes, based on systemic toxicity as evidenced by body weight gain reduction (both sexes) and high mortality (females). If the 7000 ppm dose is therefore removed from consideration, there are not significant (p < 0.05) increases in tumor formation. Moreover, a consideration of multiple comparisons reveals that the lung tumor increases observed are totally consistent with what would be expected by chance alone. Based on high susceptibility of this mouse strain for the appearance of lung tumors and the lack of a statistically significant increase in tumors by appropriate analysis, the mouse study does not indicate a carcinogenic effect of imiprothrin, and thus no classification for carcinogenicity is warranted.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
