IL-1 family cytokines in chronic inflammatory disorders. - OpacWWW

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Tytuł:: IL-1 family cytokines in chronic inflammatory disorders.
Autorzy:: Stříž I
Transliterated Title:: Cytokiny rodiny IL1 u chronických zánětlivých procesů.
Źródło:: Vnitrni lekarstvi [Vnitr Lek] 2019 Winter; Vol. 65 (2), pp. 81-85.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2010- : Brno : Ambit Media
Original Publication: 1973-<1994> : Praha : Avicenum
MeSH Terms:: Arthritis, Rheumatoid*/immunology
Cytokines*
Immune System Diseases*/immunology
Interleukin-1*
Chronic Disease ; Humans ; Immunologic Factors ; Interleukins
Contributed Indexing:: Keywords: biologic therapy; cytokines; inflammation; interleukin 1
Substance Nomenclature:: 0 (Cytokines)
0 (IL-38 protein, human)
0 (Immunologic Factors)
0 (Interleukin-1)
0 (Interleukins)
Entry Date(s):: Date Created: 20190327 Date Completed: 20190722 Latest Revision: 20190722
Update Code:: 20240105
PMID:: 30909697
: Czasopismo naukowe

IL-1 family represent a group of structurally related cytokines with prevailing pro-inflammatory (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β a IL-37γ) or anti-inflammatory (IL-1Ra, IL-36Ra, IL-38, IL-37) effects. They are involved not only in defense mechanisms and physiological modulation of homeostatic processes, but also in the imunopathogenesis of many diseases including rheumatoid arthritis, inflammatory bowel disease, autoimmune and auto-inflammatory diseases. Recently, advances in biologic therapy enabled blocking of IL-1α, IL-1β, IL-18, and IL-33 with new monoclonal antibodies, soluble receptors, or recombinant binding proteins.

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IL-1 family cytokines in chronic inflammatory disorders.