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Tytuł pozycji:

CD4 T cell count is inversely associated with lumbar spine bone mass in HIV-infected men under the age of 50 years.

Tytuł:
CD4 T cell count is inversely associated with lumbar spine bone mass in HIV-infected men under the age of 50 years.
Autorzy:
Kwak MK; Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.; Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, 04401, South Korea.; Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dontan Sacred Heart Hospital, 7, Keunjaebong-gil, Hwaseong-Si, Gyeonggi-Do, 18450, South Korea.
Lee EJ; Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, South Korea.
Park JW; Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si, Chungcheongnam-do, 31151, South Korea.
Park SY; Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, South Korea.
Kim B-; Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Kim TH; Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, South Korea.
Suh K; Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, 04401, South Korea.
Koh J-; Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Lee SH; Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea. .
Byun D-; Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, 04401, South Korea. .
Źródło:
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2019 Jul; Vol. 30 (7), pp. 1501-1510. Date of Electronic Publication: 2019 Mar 26.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: London, UK : Springer International, c1990-
MeSH Terms:
Bone Density/*immunology
CD4-Positive T-Lymphocytes/*immunology
HIV Infections/*immunology
HIV Infections/*physiopathology
Osteoporosis/*immunology
Absorptiometry, Photon/methods ; Adult ; Age Factors ; Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; Bone Density/drug effects ; CD4 Lymphocyte Count ; Case-Control Studies ; Femur Neck/physiopathology ; HIV Infections/complications ; HIV Infections/drug therapy ; Hip Joint/physiopathology ; Humans ; Lumbar Vertebrae/physiopathology ; Male ; Middle Aged ; Osteoporosis/physiopathology ; Osteoporosis/virology
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Grant Information:
2016-568 and 2017-568 Asan Institute for Life Sciences, Asan Medical Center
Contributed Indexing:
Keywords: Bone mineral density; CD4 T cell counts; HIV infection
Substance Nomenclature:
0 (Anti-HIV Agents)
Entry Date(s):
Date Created: 20190328 Date Completed: 20200113 Latest Revision: 20200324
Update Code:
20240105
DOI:
10.1007/s00198-019-04942-7
PMID:
30915506
Czasopismo naukowe
HIV-infected men under the age of 50 years had a lower bone mass compared to that of HIV-uninfected men. Lower CD4 T cell counts, independent of whether antiretroviral therapy (ART) was used, were associated with lower BMD. HIV-infected patients with low CD4 T cell counts may need follow-up and intervention regarding bone health, including younger patients.
Introduction: HIV-infected patients have a low bone mineral density (BMD) owing to multifactorial interaction between common osteoporosis risk factors and HIV-related factors, including chronic inflammation and ART. Although HIV infection and ART might affect bone metabolism, little data is available for patients aged under 50 years. We aimed to investigate the association of HIV infection-induced low CD4 T cell counts and ART with BMD in men aged under 50 years.
Methods: We performed an age- and body mass index-matched case-control study. BMD values of HIV-infected and HIV-uninfected men (< 50 years) were compared, and HIV-infected men were stratified by CD4 T cell counts and ART use.
Results: After adjusting confounders, HIV-infected men with CD4 T cell counts ≥ 500 cells/μL (n = 28) and < 500 cells/μL (n = 139) had lower BMD at the femoral neck (FN, p < 0.001) and total hip (TH, p < 0.001) than HIV-uninfected men (n = 167). HIV-infected men with CD4 T cell counts < 500/μL had lower BMD at the lumbar spine (LS, p = 0.034) than those with counts of ≥ 500 cells/μL, but not at FN and TH. The CD4 T cell count (γ = 0.169, p = 0.031) was positively correlated with BMD at LS. There was no significant difference in the BMD (p = 0.499-> 0.999) between the ART-naïve (n = 75) and ART-user group (n = 92).
Conclusions: Despite their relatively younger age, HIV-infected men had a lower BMD than HIV-uninfected men. Lower CD4 T cell counts, irrespective of ART, might result in lower bone mass.
Erratum in: Osteoporos Int. 2019 Sep 10;:. (PMID: 31506788)

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