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Tytuł pozycji:

Fine Particulate Matter and Respiratory Healthcare Encounters among Survivors of Childhood Cancers.

Tytuł :
Fine Particulate Matter and Respiratory Healthcare Encounters among Survivors of Childhood Cancers.
Autorzy :
Ou JY; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. .; Department of Internal Medicine, Division of Epidemiology, University of Utah, Salt Lake City, UT 84132, USA. .
Hanson HA; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. .; Department of Surgery, University of Utah, Salt Lake City, UT 84132, USA. .
Ramsay JM; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. .
Leiser CL; Population Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. .
Zhang Y; Department of Internal Medicine, Division of Epidemiology, University of Utah, Salt Lake City, UT 84132, USA. .
VanDerslice JA; Department of Family and Preventive Medicine, Division of Public Health, University of Utah, Salt Lake City, UT 84108, USA. .
Pope CA 3rd; Department of Economics, Brigham Young University, Provo, UT 84602, USA. .
Kirchhoff AC; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. .; Department of Pediatrics, University of Utah, Salt Lake City, UT 84108, USA. .
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Źródło :
International journal of environmental research and public health [Int J Environ Res Public Health] 2019 Mar 26; Vol. 16 (6). Date of Electronic Publication: 2019 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: Basel : MDPI, c2004-
MeSH Terms :
Air Pollutants/*analysis
Cancer Survivors/*statistics & numerical data
Emergency Service, Hospital/*statistics & numerical data
Hospitalization/*statistics & numerical data
Neoplasms/*epidemiology
Particulate Matter/*analysis
Respiratory Tract Diseases/*epidemiology
Adolescent ; Adult ; Child ; Child, Preschool ; Cross-Over Studies ; Female ; Humans ; Infant ; Infant, Newborn ; Logistic Models ; Male ; Neoplasms/drug therapy ; Young Adult
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Grant Information :
UL1 TR002538 United States TR NCATS NIH HHS
Contributed Indexing :
Keywords: air pollution*; cancer survivorship*; children*; late effects*
Substance Nomenclature :
0 (Air Pollutants)
0 (Particulate Matter)
Entry Date(s) :
Date Created: 20190329 Date Completed: 20190719 Latest Revision: 20200309
Update Code :
20210623
PubMed Central ID :
PMC6466161
DOI :
10.3390/ijerph16061081
PMID :
30917578
Czasopismo naukowe
Some chemotherapies that treat childhood cancers have pulmonary-toxic properties that increase risk for adverse respiratory-health outcomes. PM 2.5 causes similar outcomes but its effect among pulmonary compromised cancer survivors is unknown. This case-crossover study identified the PM 2.5 -associated odds for primary-respiratory hospitalizations and emergency department visits among childhood cancer survivors in Utah. We compared risk among chemotherapy-treated survivors to a cancer-free sample. We calculated 3-day-average PM 2.5 by ZIP code and county for event and control days. Conditional logistic regression estimated odds ratios. Models were stratified by cause of admission (infection, respiratory disease, asthma), previous chemotherapy, National Ambient Air Quality Standard (NAAQS), and other variables. Results are presented per 10 µg/m³ of PM 2.5 . 90% of events occurred at 3-day PM 2.5 averages <35.4 µg/m³, the NAAQS 24-h standard. For survivors, PM 2.5 was associated with respiratory hospitalizations (OR = 1.84, 95% CI = 1.13⁻3.00) and hospitalizations from respiratory infection (OR = 2.09, 95% CI = 1.06⁻4.14). Among chemotherapy-treated survivors, the PM 2.5 -associated odds of respiratory hospitalization (OR = 2.03, 95% CI = 1.14⁻3.61) were significantly higher than the cancer-free sample (OR = 0.84, 95% CI = 0.57⁻1.25). This is the first study to report significant associations between PM 2.5 and respiratory healthcare encounters in childhood cancer survivors. Chemotherapy-treated survivors displayed the highest odds of hospitalization due to PM 2.5 exposure and their risk is significantly higher than a cancer-free sample.

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