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Tytuł pozycji:

Both neural and global androgen receptor overexpression affect sexual dimorphism in the mouse brain.

Tytuł :
Both neural and global androgen receptor overexpression affect sexual dimorphism in the mouse brain.
Autorzy :
Ramzan F; Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, Canada.
Phung T; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Swift-Gallant A; Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Department of Psychology, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.
Coome LA; Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, Canada.
Holmes MM; Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Monks DA; Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
Journal of neuroendocrinology [J Neuroendocrinol] 2019 Jun; Vol. 31 (6), pp. e12715. Date of Electronic Publication: 2019 Apr 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: <2010->: Malden, MA : Wiley & Sons
Original Publication: Eynsham, Oxon, UK : Oxford University Press, c1989-
MeSH Terms :
Sex Characteristics*
Brain/*metabolism
Neurons/*metabolism
Receptors, Androgen/*metabolism
Sex Differentiation/*physiology
Animals ; Female ; Hypothalamus, Anterior/metabolism ; Male ; Mice, Transgenic ; Preoptic Area/metabolism ; Septal Nuclei/metabolism
Contributed Indexing :
Keywords: CALB-SDN*; androgen receptor*; brain*; mPOA*; sexual dimorphism*
Substance Nomenclature :
0 (Receptors, Androgen)
Entry Date(s) :
Date Created: 20190329 Date Completed: 20200814 Latest Revision: 20200814
Update Code :
20210210
DOI :
10.1111/jne.12715
PMID :
30920021
Czasopismo naukowe
Testosterone is the main endocrine mechanism mediating sexual differentiation of the mammalian brain, although testosterone signalling is complex and important mechanistic questions remain. Notably, the extent to which testosterone acts via androgen receptors (AR) in this process remains unknown and it is also not clear where testosterone acts in the body to produce sexual dimorphisms in neuroanatomy. To address these questions, we used a transgenic mouse model of Cre/loxP-driven AR overexpression in which AR was induced selectively in neural tissue (Nestin-cre) or in all tissues (CMV-cre). We then studied sexually dimorphic features of several well-characterised sexual dimorphisms: calbindin-immunoreactive neurones in the medial preoptic area (CALB-SDN), tyrosine hydroxylase neurones in the anteroventral periventricular nucleus, and vasopressin-immunoreactive neurones originating in the bed nucleus of the stria terminalis and their projections in the lateral septum. We additionally evaluated oestrogen receptor α immunoreactivity in these nuclei. Briefly, we found that global but not neural overexpression of AR resulted in masculinisation of CALB-SDN nucleus volume, cell number and cell size in transgenic females. Furthermore, neural AR overexpression resulted in increased oestrogen receptor α staining in females compared to males in the medial preoptic area. AR overexpression did not affect other measures. Overall, the results of the present study provide support for the hypothesis that androgenic mechanisms external to the nervous system can affect sexual differentiation of the brain.
(© 2019 British Society for Neuroendocrinology.)
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