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Tytuł:
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Patient-reported outcomes of symptom burden in patients receiving surgical or nonsurgical treatment for low-intermediate risk oropharyngeal squamous cell carcinoma: A comparative analysis of a prospective registry.
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Autorzy:
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Amit M; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hutcheson K; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Zaveri J; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lewin J; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kupferman ME; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hessel AC; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Goepfert RP; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Brandon Gunn G; Department of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Garden AS; Department of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ferraratto R; Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Dave Fuller C; Department of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Tam S; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Gross ND; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: .
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Źródło:
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Oral oncology [Oral Oncol] 2019 Apr; Vol. 91, pp. 13-20. Date of Electronic Publication: 2019 Feb 16.
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Typ publikacji:
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Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Oxford ; New York : Pergamon, c1997-
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MeSH Terms:
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Patient Reported Outcome Measures*
Carcinoma, Squamous Cell/*therapy
Oropharyngeal Neoplasms/*therapy
Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Prospective Studies ; Registries
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Grant Information:
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R56 DE025248 United States DE NIDCR NIH HHS
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Contributed Indexing:
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Keywords: MDASI; Oropharyngeal cancer; Patient reported outcomes; Radiation; Transoral robotic surgery
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Entry Date(s):
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Date Created: 20190331 Date Completed: 20200428 Latest Revision: 20200428
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Update Code:
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20240105
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DOI:
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10.1016/j.oraloncology.2019.01.020
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PMID:
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30926057
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Purpose: To explore treatment-related changes in symptom burden and quality of life (QOL) in oropharyngeal squamous cell cancer (OPSCC) patients treated surgically and non-surgically.
Patients and Methods: Eighty-six patients with human papillomavirus-associated OPSCC treated at the Head and Neck Center at The University of Texas MD Anderson Cancer Center were recruited to a prospective registry study between 2014 and 2016 and completed the core, head and neck-specific, and symptom interference sections of the MD Anderson symptom inventory (MDASI) multi-symptom questionnaire and the EQ-5D health status assessment as a measure of QOL at four time points.
Results: Longitudinal improvements from post-treatment nadir were observed across all groups. For patients treated with single modality, symptom interference, but not core and head and neck specific, MDASI scores were significantly better at 6 months in patients treated with surgery than radiation (P = 0.04). For patients treated with multiple modalities, scores for each of the three domains (i.e., core, head and neck -specific, and interference MDASI) were significantly better in the surgical group than the nonsurgical group at treatment completion (P = 0.0003, P = 0.0006 and P = 0.02) and 6 weeks (P = 0.001, P = 0.05 and P = 0.04), but not 6 months (P = 0.11, P = 0.16 and P = 0.040). No significant differences in EQ5D health status were observed between groups at any time point, reflecting similar overall QOL in all groups.
Conclusion: Symptom burden and QOL improves after treatment in OPSCC survivors over time regardless of whether primary surgical or nonsurgical treatment is used, although acute symptom profiles may differ.
(Copyright © 2019. Published by Elsevier Ltd.)
