-
Tytuł:
-
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.
-
Autorzy:
-
Garrett-Bakelman FE; Weill Cornell Medicine, New York, NY, USA.; University of Virginia School of Medicine, Charlottesville, VA, USA.
Darshi M; Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.
Green SJ; University of Illinois at Chicago, Chicago, IL, USA.
Gur RC; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Lin L; Stanford University School of Medicine, Palo Alto, CA, USA.
Macias BR; KBRwyle, Houston, TX, USA.
McKenna MJ; Colorado State University, Fort Collins, CO, USA.
Meydan C; Weill Cornell Medicine, New York, NY, USA.; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA.
Mishra T; Stanford University School of Medicine, Palo Alto, CA, USA.
Nasrini J; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Piening BD; Stanford University School of Medicine, Palo Alto, CA, USA.
Rizzardi LF; Johns Hopkins University, Baltimore, MD, USA.
Sharma K; Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.
Siamwala JH; University of California, San Diego, La Jolla, CA, USA.
Taylor L; Colorado State University, Fort Collins, CO, USA.
Vitaterna MH; Northwestern University, Evanston, IL, USA.
Afkarian M; University of California, Davis, Davis, CA, USA.
Afshinnekoo E; Weill Cornell Medicine, New York, NY, USA.; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA.
Ahadi S; Stanford University School of Medicine, Palo Alto, CA, USA.
Ambati A; Stanford University School of Medicine, Palo Alto, CA, USA.
Arya M; KBRwyle, Houston, TX, USA.
Bezdan D; Weill Cornell Medicine, New York, NY, USA.; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA.
Callahan CM; Johns Hopkins University, Baltimore, MD, USA.
Chen S; Stanford University School of Medicine, Palo Alto, CA, USA.
Choi AMK; Weill Cornell Medicine, New York, NY, USA.
Chlipala GE; University of Illinois at Chicago, Chicago, IL, USA.
Contrepois K; Stanford University School of Medicine, Palo Alto, CA, USA.
Covington M; National Aeronautics and Space Administration (NASA), Houston, TX, USA.
Crucian BE; National Aeronautics and Space Administration (NASA), Houston, TX, USA.
De Vivo I; Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Dinges DF; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Ebert DJ; KBRwyle, Houston, TX, USA.
Feinberg JI; Johns Hopkins University, Baltimore, MD, USA.
Gandara JA; Weill Cornell Medicine, New York, NY, USA.
George KA; KBRwyle, Houston, TX, USA.
Goutsias J; Johns Hopkins University, Baltimore, MD, USA.
Grills GS; Weill Cornell Medicine, New York, NY, USA.
Hargens AR; University of California, San Diego, La Jolla, CA, USA.
Heer M; University of Bonn, Bonn, Germany.
Hillary RP; Stanford University School of Medicine, Palo Alto, CA, USA.
Hoofnagle AN; University of Washington, Seattle, WA, USA.
Hook VYH; University of California, San Diego, La Jolla, CA, USA.
Jenkinson G; Johns Hopkins University, Baltimore, MD, USA.
Jiang P; Northwestern University, Evanston, IL, USA.
Keshavarzian A; Rush University Medical Center, Chicago, IL, USA.
Laurie SS; KBRwyle, Houston, TX, USA.
Lee-McMullen B; Stanford University School of Medicine, Palo Alto, CA, USA.
Lumpkins SB; MEI Technologies, Houston, TX, USA.
MacKay M; Weill Cornell Medicine, New York, NY, USA.
Maienschein-Cline MG; University of Illinois at Chicago, Chicago, IL, USA.
Melnick AM; Weill Cornell Medicine, New York, NY, USA.
Moore TM; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Nakahira K; Weill Cornell Medicine, New York, NY, USA.
Patel HH; University of California, San Diego, La Jolla, CA, USA.
Pietrzyk R; KBRwyle, Houston, TX, USA.
Rao V; Stanford University School of Medicine, Palo Alto, CA, USA.
Saito R; University of California, San Diego, La Jolla, CA, USA.
Salins DN; Stanford University School of Medicine, Palo Alto, CA, USA.
Schilling JM; University of California, San Diego, La Jolla, CA, USA.
Sears DD; University of California, San Diego, La Jolla, CA, USA.
Sheridan CK; Weill Cornell Medicine, New York, NY, USA.
Stenger MB; National Aeronautics and Space Administration (NASA), Houston, TX, USA.
Tryggvadottir R; Johns Hopkins University, Baltimore, MD, USA.
Urban AE; Stanford University School of Medicine, Palo Alto, CA, USA.
Vaisar T; University of Washington, Seattle, WA, USA.
Van Espen B; University of California, San Diego, La Jolla, CA, USA.
Zhang J; Stanford University School of Medicine, Palo Alto, CA, USA.
Ziegler MG; University of California, San Diego, La Jolla, CA, USA.
Zwart SR; University of Texas Medical Branch, Galveston, TX, USA.
Charles JB; National Aeronautics and Space Administration (NASA), Houston, TX, USA. _b_.
Kundrot CE; Space Life and Physical Sciences Division, NASA Headquarters, Washington, DC, USA. _b_.
Scott GBI; National Space Biomedical Research Institute, Baylor College of Medicine, Houston, TX, USA. _b_.
Bailey SM; Colorado State University, Fort Collins, CO, USA. _b_.
Basner M; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. _b_.
Feinberg AP; Johns Hopkins University, Baltimore, MD, USA. _b_.
Lee SMC; KBRwyle, Houston, TX, USA. _b_.
Mason CE; Weill Cornell Medicine, New York, NY, USA. _b_.; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA.; The Feil Family Brain and Mind Research Institute, New York, NY, USA.; The WorldQuant Initiative for Quantitative Prediction, New York, NY, USA.
Mignot E; Stanford University School of Medicine, Palo Alto, CA, USA. _b_.
Rana BK; University of California, San Diego, La Jolla, CA, USA. _b_.
Smith SM; National Aeronautics and Space Administration (NASA), Houston, TX, USA. _b_.
Snyder MP; Stanford University School of Medicine, Palo Alto, CA, USA. _b_.
Turek FW; Northwestern University, Evanston, IL, USA. _b_.
-
Źródło:
-
Science (New York, N.Y.) [Science] 2019 Apr 12; Vol. 364 (6436).
-
Typ publikacji:
-
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Twin Study
-
Język:
-
English
-
Imprint Name(s):
-
Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-
-
MeSH Terms:
-
Adaptation, Physiological*
Astronauts*
Space Flight*
Adaptive Immunity ; Body Weight ; Carotid Arteries/diagnostic imaging ; Carotid Intima-Media Thickness ; DNA Damage ; DNA Methylation ; Gastrointestinal Microbiome ; Genomic Instability ; Humans ; Male ; Telomere Homeostasis ; Time Factors ; United States ; United States National Aeronautics and Space Administration
-
References:
-
Front Immunol. 2017 Apr 03;8:367. (PMID: 28421073)
J Physiol. 2015 Feb 1;593(3):573-84. (PMID: 25774397)
Aging (Albany NY). 2016 Jan;8(1):12-5. (PMID: 26826704)
Am J Physiol Heart Circ Physiol. 2016 Mar 1;310(5):H628-38. (PMID: 26747504)
Curr Opin Immunol. 2013 Jun;25(3):321-8. (PMID: 23747000)
Nutr Cancer. 2016 Nov-Dec;68(8):1269-1280. (PMID: 27689688)
FASEB J. 2016 Jan;30(1):141-8. (PMID: 26316272)
FASEB J. 2017 Sep;31(9):3746-3756. (PMID: 28546443)
Aerosp Med Hum Perform. 2015 Dec;86(12 Suppl):A54-A67. (PMID: 26630196)
Acta Naturae. 2013 Jul;5(3):116-25. (PMID: 24303207)
Nature. 2012 Jun 13;486(7402):207-14. (PMID: 22699609)
Biochem Biophys Res Commun. 2012 Feb 24;418(4):799-805. (PMID: 22310713)
Mol Cell Proteomics. 2015 Jun;14(6):1684-95. (PMID: 25787789)
J Appl Physiol (1985). 2001 Aug;91(2):645-53. (PMID: 11457776)
Hum Mol Genet. 1996 May;5(5):685-91. (PMID: 8733138)
Environ Mol Mutagen. 2013 Apr;54(3):172-9. (PMID: 23401031)
Microbiome. 2017 Mar 24;5(1):39. (PMID: 28340597)
Nature. 2013 Jul 18;499(7458):306-11. (PMID: 23868260)
Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):28-34. (PMID: 21102320)
Med Sci Sports Exerc. 2000 Oct;32(10):1743-7. (PMID: 11039647)
Nat Biotechnol. 2014 Sep;32(9):915-925. (PMID: 25150835)
Aviat Space Environ Med. 1987 Sep;58(9 Pt 2):A91-6. (PMID: 3675513)
Cell. 1985 Dec;43(2 Pt 1):405-13. (PMID: 3907856)
PLoS One. 2014 Apr 23;9(4):e96099. (PMID: 24759903)
Nucleic Acids Res. 2009 Feb;37(3):e21. (PMID: 19129229)
Eur J Appl Physiol. 2015 Oct;115(10):2099-106. (PMID: 25991027)
Aviat Space Environ Med. 2011 Feb;82(2):144-6. (PMID: 21329032)
J Intern Med. 2006 May;259(5):493-519. (PMID: 16629855)
Physiol Rev. 2018 Jan 1;98(1):59-87. (PMID: 29167331)
Circulation. 2007 Jan 30;115(4):459-67. (PMID: 17242284)
Aviat Space Environ Med. 1987 Sep;58(9 Pt 2):A86-90. (PMID: 3675511)
Nat Biotechnol. 2014 Sep;32(9):903-14. (PMID: 25150838)
J Appl Physiol (1985). 1996 Jul;81(1):105-16. (PMID: 8828652)
Mol Genet Metab. 2016 Jun;118(2):138-42. (PMID: 27157420)
Ageing Res Rev. 2016 Jan;25:55-69. (PMID: 26616852)
Mutat Res. 2013 Aug 30;756(1-2):165-9. (PMID: 23639573)
Arch Intern Med. 2008 Jan 28;168(2):154-8. (PMID: 18227361)
Aviat Space Environ Med. 2010 Feb;81(2):91-102. (PMID: 20131648)
Med Sci Sports Exerc. 2018 Sep;50(9):1961-1980. (PMID: 29620686)
J Appl Physiol (1985). 2009 Apr;106(4):1159-68. (PMID: 19150852)
Adv Exp Med Biol. 2014;802:5-29. (PMID: 24443018)
J Gerontol A Biol Sci Med Sci. 2006 Dec;61(12):1262-6. (PMID: 17234819)
Oncotarget. 2017 Jul 4;8(27):45008-45019. (PMID: 28410238)
J Neuroophthalmol. 2013 Sep;33(3):249-55. (PMID: 23851997)
Int J Obes (Lond). 2016 May;40(5):773-8. (PMID: 26607038)
J Nutr Biochem. 2012 Jul;23(7):817-21. (PMID: 21889886)
Aviat Space Environ Med. 2014 Sep;85(9):897-904. (PMID: 25197887)
Life Sci Space Res (Amst). 2016 Aug;10:53-6. (PMID: 27662788)
Hypertension. 2014 Jul;64(1):149-56. (PMID: 24777983)
Immunity. 2014 May 15;40(5):692-705. (PMID: 24792914)
Mutat Res. 2010 Aug 14;701(1):75-9. (PMID: 20176126)
Bone. 2015 Dec;81:712-720. (PMID: 26456109)
Sci Rep. 2018 Mar 8;8(1):4191. (PMID: 29520055)
Nat Commun. 2016 Sep 12;7:12605. (PMID: 27615322)
Biochimie. 2009 Jun;91(6):791-5. (PMID: 19455748)
Front Oncol. 2015 Nov 24;5:257. (PMID: 26636039)
J Nutr. 2012 Mar;142(3):427-31. (PMID: 22298570)
Peptides. 2011 Oct;32(10):2141-50. (PMID: 21945916)
Aviat Space Environ Med. 2010 Nov;81(11):1024-7. (PMID: 21043299)
Aerosp Med Hum Perform. 2015 Nov;86(11):942-52. (PMID: 26564759)
Mutat Res. 2006 Oct 10;601(1-2):19-29. (PMID: 16765996)
Annu Rev Nutr. 2014;34:377-400. (PMID: 24995691)
Mol Aspects Med. 2012 Oct-Dec;33(5-6):535-46. (PMID: 23078817)
Front Immunol. 2018 Jun 28;9:1437. (PMID: 30018614)
J Bone Miner Res. 2012 Sep;27(9):1896-906. (PMID: 22549960)
Mutat Res Genet Toxicol Environ Mutagen. 2018 Dec;836(Pt A):28-35. (PMID: 30389158)
Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):661-70. (PMID: 17170368)
Aerosp Med Hum Perform. 2016 May;87(5):449-53. (PMID: 27099083)
J Immunol Res. 2016;2016:5371050. (PMID: 26977417)
Clin Chem. 2001 Mar;47(3):519-24. (PMID: 11238306)
Biochem Biophys Res Commun. 1997 Feb 24;231(3):835-8. (PMID: 9070905)
J Am Heart Assoc. 2017 Aug 7;6(8):. (PMID: 28784652)
PLoS Genet. 2016 Jul 07;12(7):e1006144. (PMID: 27386863)
Exp Eye Res. 2001 Aug;73(2):221-8. (PMID: 11446772)
Neurobiol Aging. 2015 Oct;36(10):2785-90. (PMID: 26239175)
Nat Genet. 2017 May;49(5):719-729. (PMID: 28346445)
Chromosome Res. 2013 Apr;21(2):165-74. (PMID: 23572395)
Psychosom Med. 2001 Nov-Dec;63(6):865-73. (PMID: 11719623)
Ophthalmology. 2011 Oct;118(10):2058-69. (PMID: 21849212)
Radiat Environ Biophys. 2014 May;53(2):255-63. (PMID: 24477407)
-
Grant Information:
-
K01 AG035031 United States AG NIA NIH HHS; K12 HL120001 United States HL NHLBI NIH HHS; P30 DK017047 United States DK NIDDK NIH HHS; P30 DK035816 United States DK NIDDK NIH HHS
-
Entry Date(s):
-
Date Created: 20190413 Date Completed: 20190509 Latest Revision: 20220409
-
Update Code:
-
20240104
-
PubMed Central ID:
-
PMC7580864
-
DOI:
-
10.1126/science.aau8650
-
PMID:
-
30975860
-
To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intima-media thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight.
(Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
Comment in: Science. 2019 Apr 12;364(6436):127-128. (PMID: 30975876)
Comment in: Nat Med. 2019 May;25(5):710. (PMID: 31068707)
Zaloguj się, aby uzyskać dostęp do pełnego tekstu.
