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Tytuł pozycji:

Eye hazard classification according to UN GHS / EU CLP and the severity of eye symptoms caused by accidental exposures to detergents and cleaning products.

Tytuł:
Eye hazard classification according to UN GHS / EU CLP and the severity of eye symptoms caused by accidental exposures to detergents and cleaning products.
Autorzy:
Scazzola R; A.I.S.E. (International Association for Soaps, Detergents and Maintenance Products), Belgium. Electronic address: .
Boeije G; Boeije Consulting bvba, Belgium.
Bøtker Pedersen E; Danish Poisons Centre, Bispebjerg Hospital, København, Denmark.
Brenneman W; Procter & Gamble, USA.
Cagáňová B; National Toxicological Information Centre, University Hospital Bratislava, Slovakia.
Celentano A; Centro Antiveleni di Milano, Azienda Ospedaliera Niguarda Ca' Granda, Italy.
De Coninck E; Procter & Gamble, Belgium.
Desel H; BfR (German Federal Institute for Risk Assessment), Germany, Formerly GIZ-Nord Poisons Center, University Medical Center Göttingen, Germany.
Ebbehøj N; Danish Poisons Centre, Bispebjerg Hospital, København, Denmark.
Färber E; GIZ-Nord Poisons Centre, University Medical Center Göttingen, Germany.
Sesana F; Centro Antiveleni di Milano, Azienda Ospedaliera Niguarda Ca' Granda, Italy.
Zacharov S; Toxicological Information Centre, Department of Occupational Medicine, First Faculty of Medicine, Charles University and General University Hospital Prague, Czech Republic.
Źródło:
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Jul; Vol. 105, pp. 69-76. Date of Electronic Publication: 2019 Apr 09.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: <2003>- : Amsterdam : Elsevier
Original Publication: New York : Academic Press, [c1981-
MeSH Terms:
Detergents/*toxicity
Eye Injuries/*classification
Irritants/*toxicity
Animals ; Eye Injuries/etiology ; Humans ; Poison Control Centers ; Trauma Severity Indices
Contributed Indexing:
Keywords: Accidental eye exposure; Detergents and cleaning products; EU CLP; EU DPD; Eye hazard classification category; Poisoning severity score (PSS); UN GHS
Substance Nomenclature:
0 (Detergents)
0 (Irritants)
Entry Date(s):
Date Created: 20190413 Date Completed: 20190708 Latest Revision: 20190708
Update Code:
20240104
DOI:
10.1016/j.yrtph.2019.04.004
PMID:
30978367
Czasopismo naukowe
The use of lower cut-off values/concentration limits for the calculation of mixture classification in UN GHS/EU CLP versus the previous regulatory scheme (EU Dangerous Preparations Directive, DPD), has resulted in an increased number of classifications in the highest eye hazard category. Herein, a semi-quantitative categorisation of severity of eye effects, following accidental human exposures to detergents, was compared to the classification category of the products. Three schemes were evaluated: EU DPD; EU CLP (based on all available data and information, including weight of evidence); and EU CLP (based entirely on the calculation method). As reported by four EU Poison Centres, the vast majority of exposures had caused minor or no symptoms. Classification was a poor predictor of effects in man subjected to accidental exposure. Note however that this is also because effects are not only driven by the intrinsic hazard (as reflected in the classification), but also by the exposure conditions and mitigation (i.e. rinsing). EU CLP classification using all available data and information was more predictive of medically relevant symptoms than the EU CLP calculation method. The latter led to a poorer differentiation between irritating products versus products potentially causing serious eye damage.
(Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)

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