Membrane Permeabilization Mechanisms.

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Abstrakt

Tytuł:: Membrane Permeabilization Mechanisms.
Autorzy:: Matsuzaki K; Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan. .
Źródło:: Advances in experimental medicine and biology [Adv Exp Med Biol] 2019; Vol. 1117, pp. 9-16.
Typ publikacji:: Journal Article; Review
Język:: English
Imprint Name(s):: Publication: 1998- : New York : Kluwer Academic/Plenum Publishers
Original Publication: New York, Plenum Press.
MeSH Terms:: Cell Membrane Permeability*
Antimicrobial Cationic Peptides/*physiology
Animals ; Cell Membrane ; Lipid Bilayers
Contributed Indexing:: Keywords: Barrel-stave model; Carpet model; Membrane binding; Membrane curvature; Membrane permeabilization; Toroidal pore model
Substance Nomenclature:: 0 (Antimicrobial Cationic Peptides)
0 (Lipid Bilayers)
Entry Date(s):: Date Created: 20190414 Date Completed: 20190801 Latest Revision: 20190801
Update Code:: 20240104
DOI:: 10.1007/978-981-13-3588-4_2
PMID:: 30980350
: Czasopismo naukowe

Many antimicrobial peptides are considered to kill microbes by permeabilizing cell membranes. This chapter summarizes the driving force of peptide binding to membranes; various mechanisms of lipid bilayer permeabilization including the barrel-stave, toroidal pore, and carpet models; and modes of permeabilization of bacterial and mammalian membranes.

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