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Tytuł:
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Impact of subthalamic nucleus stimulation did not differ on young-onset and older-onset Parkinson's disease: A three-year follow up.
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Autorzy:
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Zhang J; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, Hunan, People's Republic of China.
Jia G; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, Hunan, People's Republic of China.
Yang Z; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, Hunan, People's Republic of China.
Liu D; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, Hunan, People's Republic of China.
Hou Y; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, Hunan, People's Republic of China.
Wang Y; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, Hunan, People's Republic of China.
Yang Z; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, Hunan, People's Republic of China. Electronic address: .
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Źródło:
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Neuroscience letters [Neurosci Lett] 2019 Jul 13; Vol. 705, pp. 99-105. Date of Electronic Publication: 2019 Apr 25.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Limerick : Elsevier Scientific Publishers Ireland
Original Publication: Amsterdam, Elsevier/North-Holland.
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MeSH Terms:
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Deep Brain Stimulation*
Parkinson Disease/*therapy
Subthalamic Nucleus/*physiology
Adult ; Age of Onset ; Aged ; Combined Modality Therapy/methods ; Female ; Follow-Up Studies ; Humans ; Levodopa/therapeutic use ; Male ; Middle Aged ; Parkinson Disease/drug therapy ; Quality of Life ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome
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Contributed Indexing:
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Keywords: Deep brain stimulation; Long-term effects; Older-onset; Parkinson’s disease; Young-onset
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Substance Nomenclature:
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46627O600J (Levodopa)
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Entry Date(s):
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Date Created: 20190428 Date Completed: 20191223 Latest Revision: 20191223
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Update Code:
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20240105
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DOI:
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10.1016/j.neulet.2019.04.041
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PMID:
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31028845
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Objective: To assess the role of onset age in the results of bilateral subthalamic nucleus deep brain stimulation (STN-DBS), we carried out a retrospective study of two groups of patients regarding age at disease onset.
Methods: We compared, up to 3 years after surgery, the clinical effects, quality of life and the levodopa equivalent daily dose (LEDD) in patients with young-onset Parkinson's disease (onset age <50 years, YOPD) vs patients with older-onset Parkinson's disease (onset age ≥50 years, OOPD).
Results: A dramatic improvement in motor symptoms was equally observed in both groups of patients after DBS. The improvements of the Unified Parkinson's Disease Rating Scale part III motor scale (UPDRS-III) score, axial sub-score and non-axial sub-score from baseline gradually decreased over time. The benefit of STN-DBS for the axial symptoms decreased most rapidly, which directly resulted in a progressive decline in stimulation efficacy in both groups. Nevertheless, the improvement in non-axial symptoms after DBS was remarkable and long-lasting. The quality of life in both groups were also improved after DBS but were slightly decreased in the following years. The reduced LEDD were equivalent in both groups.
Conclusions: STN-DBS alleviates motor symptoms and improves quality of life equally in both YOPD and OOPD patients with similar LEDD. The initial therapeutic benefit of STN-DBS for PD gradually decreases over time, mainly due to the progression of PD and the rapid withdrawal of the benefit for axial symptoms.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
