Circulating cell death biomarker TRAIL is associated with increased organ dysfunction in sepsis.

Szczegóły
Abstrakt

Tytuł:: Circulating cell death biomarker TRAIL is associated with increased organ dysfunction in sepsis.
Autorzy:: Schenck EJ; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York, USA.; New York-Presbyterian Hospital Weill Cornell Medical Center, New York, New York, USA.
Ma KC; Section of Interventional Pulmonology and Thoracic Oncology, Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Price DR; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York, USA.; New York-Presbyterian Hospital Weill Cornell Medical Center, New York, New York, USA.
Nicholson T; New York-Presbyterian Hospital Weill Cornell Medical Center, New York, New York, USA.
Oromendia C; Department of Healthcare Policy and Research, Division of Biostatistics and Epidemiology, Weill Cornell Medicine, New York, New York, USA.
Gentzler ER; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Sanchez E; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Baron RM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Fredenburgh LE; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Huh JW; Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Ulsan, South Korea.
Siempos II; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York, USA.; First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, University of Athens Medical School, Athens, Greece.
Choi AM; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, New York, USA.; New York-Presbyterian Hospital Weill Cornell Medical Center, New York, New York, USA.
Źródło:: JCI insight [JCI Insight] 2019 May 02; Vol. 4 (9). Date of Electronic Publication: 2019 May 02 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Original Publication: Ann Arbor, Michigan : American Society for Clinical Investigation, [2016]-
MeSH Terms:: Apoptosis*
Biomarkers/*blood
Multiple Organ Failure/*blood
Sepsis/*blood
TNF-Related Apoptosis-Inducing Ligand/*blood
Adolescent ; Adult ; Aged ; Cell Death ; Critical Illness ; Female ; Hospital Mortality ; Humans ; Intensive Care Units ; Male ; Middle Aged ; New York ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Sepsis/mortality ; Shock, Septic/blood ; Young Adult
References:: Nature. 2005 Mar 3;434(7029):88-93. (PMID: 15744305)
J Leukoc Biol. 2006 Jan;79(1):123-32. (PMID: 16244105)
Nat Rev Immunol. 2006 Nov;6(11):813-22. (PMID: 17039247)
Crit Care Med. 2010 Nov;38(11):2169-74. (PMID: 20657274)
JAMA. 2011 Dec 21;306(23):2614-5. (PMID: 22187284)
Immunity. 2011 Dec 23;35(6):908-18. (PMID: 22195746)
Am J Respir Crit Care Med. 2012 Jun 1;185(11):1225-34. (PMID: 22461369)
J Exp Med. 2012 Oct 22;209(11):1937-52. (PMID: 23071253)
J Exp Med. 2012 Oct 22;209(11):1903-6. (PMID: 23091198)
Cytokine. 2013 Feb;61(2):676-81. (PMID: 23317877)
Crit Rev Immunol. 2013;33(1):23-40. (PMID: 23510024)
PLoS One. 2013 Dec 12;8(12):e82204. (PMID: 24349222)
N Engl J Med. 2014 Jan 30;370(5):455-65. (PMID: 24476434)
Science. 2014 Mar 21;343(6177):1357-60. (PMID: 24557836)
Proc Natl Acad Sci U S A. 2014 May 20;111(20):7391-6. (PMID: 24799678)
JAMA. 2014 Jul 2;312(1):90-2. (PMID: 24838355)
Lancet Infect Dis. 2015 May;15(5):581-614. (PMID: 25932591)
JAMA. 2016 Feb 23;315(8):762-74. (PMID: 26903335)
JAMA. 2016 Feb 23;315(8):801-10. (PMID: 26903338)
PLoS One. 2016 Apr 28;11(4):e0153765. (PMID: 27124414)
Nat Rev Immunol. 2017 Feb;17(2):97-111. (PMID: 27748397)
Annu Rev Pathol. 2017 Jan 24;12:103-130. (PMID: 27959630)
Nat Rev Dis Primers. 2016 Jun 30;2:16045. (PMID: 28117397)
Nat Rev Immunol. 2017 Mar;17(3):151-164. (PMID: 28138137)
Mol Cell. 2017 Mar 16;65(6):965-973. (PMID: 28306512)
Crit Care. 2017 Mar 26;21(1):73. (PMID: 28342442)
Nat Rev Cancer. 2017 May 24;17(6):352-366. (PMID: 28536452)
Am J Respir Crit Care Med. 2018 Feb 1;197(3):300-309. (PMID: 28977759)
BMC Pulm Med. 2017 Dec 15;17(1):204. (PMID: 29246207)
Crit Care Med. 2018 May;46(5):791-798. (PMID: 29443814)
JCI Insight. 2018 May 3;3(9):. (PMID: 29720570)
Intensive Care Med. 2018 Jul;44(7):1039-1049. (PMID: 29808345)
JCI Insight. 2018 Jul 12;3(13):. (PMID: 29997296)
Immunity. 2018 Jul 17;49(1):42-55.e6. (PMID: 30021146)
Ann Am Thorac Soc. 2019 Jan;16(1):22-28. (PMID: 30230362)
Crit Care Med. 2019 Feb;47(2):264-267. (PMID: 30247240)
Crit Care Med. 1985 Oct;13(10):818-29. (PMID: 3928249)
Intensive Care Med. 1996 Jul;22(7):707-10. (PMID: 8844239)
Grant Information:: KL2 TR002385 United States TR NCATS NIH HHS; P01 HL114501 United States HL NHLBI NIH HHS; R01 HL055330 United States HL NHLBI NIH HHS
Contributed Indexing:: Keywords: Apoptosis; Immunology; Inflammation
Substance Nomenclature:: 0 (Biomarkers)
0 (TNF-Related Apoptosis-Inducing Ligand)
0 (TNFSF10 protein, human)
EC 2.7.11.1 (RIPK3 protein, human)
EC 2.7.11.1 (Receptor-Interacting Protein Serine-Threonine Kinases)
Entry Date(s):: Date Created: 20190503 Date Completed: 20200908 Latest Revision: 20201029
Update Code:: 20240105
PubMed Central ID:: PMC6538332
DOI:: 10.1172/jci.insight.127143
PMID:: 31045578
: Czasopismo naukowe

Background: In sepsis, there may be dysregulation in programed cell death pathways, typified by apoptosis and necroptosis. Programmed cell death pathways may contribute to variability in the immune response. TRAIL is a potent inducer of apoptosis. Receptor-interacting serine/threonine protein kinase-3 (RIPK3) is integral to the execution of necroptosis. We explored whether plasma TRAIL levels were associated with in-hospital mortality, organ dysfunction, and septic shock. We also explored the relationship between TRAIL and RIPK3.
Methods: We performed an observational study of critically ill adults admitted to intensive care units at 3 academic medical centers across 2 continents, using 1 as derivation and the other 2 as validation cohorts. Levels of TRAIL were measured in the plasma of 570 subjects by ELISA.
Results: In all cohorts, lower (<28.5 pg/ml) versus higher levels of TRAIL were associated with increased organ dysfunction (P ≤ 0.002) and septic shock (P ≤ 0.004). Lower TRAIL levels were associated with in-hospital mortality in 2 of 3 cohorts (Weill Cornell-Biobank of Critical Illness, P = 0.012; Brigham and Women's Hospital Registry of Critical Illness, P = 0.011; Asan Medical Center, P = 0.369). Lower TRAIL was also associated with increased RIPK3 (P ≤ 0.001).
Conclusion: Lower levels of TRAIL were associated with septic shock and organ dysfunction in 3 independent ICU cohorts. TRAIL was inversely associated with RIPK3 in all cohorts.
Funding: NIH (R01-HL055330 and KL2-TR002385).

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