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Tytuł:
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An occupational exposure limit (OEL) approach to protect home healthcare workers exposed to common nebulized drugs.
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Autorzy:
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Frank E; University of Cincinnati, College of Medicine, Department of Environmental Health, USA.
Ishau S; University of Cincinnati, College of Medicine, Department of Environmental Health, USA.
Maier A; University of Cincinnati, College of Medicine, Department of Environmental Health, and Cardno ChemRisk, USA.
Reutman S; University of Cincinnati, College of Nursing, USA.
Reichard JF; University of Cincinnati, College of Medicine, Department of Environmental Health, USA. Electronic address: .
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Źródło:
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Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2019 Aug; Vol. 106, pp. 251-261. Date of Electronic Publication: 2019 Apr 29.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: <2003>- : Amsterdam : Elsevier
Original Publication: New York : Academic Press, [c1981-
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MeSH Terms:
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Health Personnel*
Occupational Health*
Budesonide/*analysis
Ipratropium/*analysis
Occupational Exposure/*analysis
Budesonide/adverse effects ; Budesonide/pharmacokinetics ; Humans ; Ipratropium/adverse effects ; Ipratropium/pharmacokinetics ; Occupational Exposure/adverse effects ; Risk Assessment
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Contributed Indexing:
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Keywords: Acceptable daily exposure or OEL; Albuterol; Budesonide; Ipratropium; Nebulizer; Pharmaceutical risk assessment
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Substance Nomenclature:
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51333-22-3 (Budesonide)
GR88G0I6UL (Ipratropium)
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Entry Date(s):
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Date Created: 20190504 Date Completed: 20200213 Latest Revision: 20200213
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Update Code:
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20240105
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DOI:
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10.1016/j.yrtph.2019.04.021
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PMID:
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31047944
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Home healthcare is a growing area of employment. Assessment of occupational health risks to home health care workers (HHCWs) is important because in many cases the unique characteristics of the home environment do not facilitate the level of exposure control afforded to caregivers in hospitals and other fixed patient care sites. This assessment is focused on health risks to HHCWs from exposure to pharmaceutical drugs used to treat asthma and other respiratory diseases, which are commonly administered to patients in aerosolized form via nebulizers. We developed risk-based exposure limits for workers in the form of occupational exposure limits (OEL) values for exposure to nebulized forms of the three most common drugs administered by this method: albuterol, ipratropium, and budesonide. The derived OEL for albuterol was 2 μg/day, for ipratropium was 30 μg/day, and for budesonide was 11 μg/day. These OELs were derived based on human effect data and adjusted for pharmacokinetic variability and areas of uncertainty relevant to the underlying data (human and non-human) available for each drug. The resulting OEL values provide an input to the occupational risk assessment process to allow for comparisons to HHCW exposure that will guide risk management and exposure control decisions.
(Copyright © 2019. Published by Elsevier Inc.)