Dissipation studies of famoxadone in vegetables under greenhouse conditions using liquid chromatography coupled to high-resolution mass spectrometry: putative elucidation of a new metabolite.

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Tytuł:: Dissipation studies of famoxadone in vegetables under greenhouse conditions using liquid chromatography coupled to high-resolution mass spectrometry: putative elucidation of a new metabolite.
Autorzy:: López-Ruiz R; Research Group 'Analytical Chemistry of Contaminants', Department of Chemistry and Physics, Research Centre for Agricultural and Food Biotechnology (BITAL), Agrifood Campus of International Excellence, University of Almeria, Almeria, Spain.
Romero-González R; Research Group 'Analytical Chemistry of Contaminants', Department of Chemistry and Physics, Research Centre for Agricultural and Food Biotechnology (BITAL), Agrifood Campus of International Excellence, University of Almeria, Almeria, Spain.
Ortega-Carrasco E; Lead Molecular Design, SL Valle's, Barcelona, Spain.
Garrido Frenich A; Research Group 'Analytical Chemistry of Contaminants', Department of Chemistry and Physics, Research Centre for Agricultural and Food Biotechnology (BITAL), Agrifood Campus of International Excellence, University of Almeria, Almeria, Spain.
Źródło:: Journal of the science of food and agriculture [J Sci Food Agric] 2019 Sep; Vol. 99 (12), pp. 5368-5376. Date of Electronic Publication: 2019 Jun 05.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: <2005-> : Chichester, West Sussex : John Wiley & Sons
Original Publication: London, Society of Chemical Industry.
MeSH Terms:: Cucumis sativus/*chemistry
Solanum lycopersicum/*chemistry
Strobilurins/*chemistry
Vegetables/*chemistry
Chromatography, High Pressure Liquid ; Cucumis sativus/growth & development ; Cucumis sativus/metabolism ; Germany ; Humans ; Solanum lycopersicum/growth & development ; Solanum lycopersicum/metabolism ; Mass Spectrometry ; Strobilurins/metabolism ; Vegetables/growth & development ; Vegetables/metabolism
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Grant Information:: PTQ-15-07464 E.O-C. thanks to the Spanish Ministry of Science and Innovation and the European Regional Development Fund (FEDER) for the Torres Quevedo Project grant; RLR acknowledges "Plan Propio of Investigation" of University of Almería, cofinanced by CAJAMAR and the Operational Program Funds Europeans of Regional Development of Andalusia (2014-2020) (FEDER), for financial support; The development of MassChemSite software has been co-funded by the European Union through the European Regional Development Fund (FEDER) and ACCIÓ
Contributed Indexing:: Keywords: UHPLC-Orbitrap-MS; dissipation; famoxadone; greenhouse conditions; metabolites; putative identification
Substance Nomenclature:: 0 (Strobilurins)
V1C07OR6II (famoxadone)
Entry Date(s):: Date Created: 20190508 Date Completed: 20190912 Latest Revision: 20221207
Update Code:: 20240105
DOI:: 10.1002/jsfa.9794
PMID:: 31062362
: Czasopismo naukowe

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Background: Famoxadone is a pesticide that is used to control fungal diseases and its dissipation in vegetables should be monitored. For that purpose, liquid chromatography coupled to mass spectrometry has been used.
Results: The dissipation of famoxadone has been monitored in cucumber, cherry tomato and courgette under greenhouse conditions at different doses (single and double), using ultra high-performance liquid chromatography coupled to Orbitrap mass spectrometry (Thermo Fisher Scientific, Bremen, Germany). The concentration of famoxadone increased slightly just after the application of the commercial product and then decreased. The half-lives (DT 50 ) of famoxadone are different for each matrix, ranging from 2 days (courgette single dose) to 10 days (cucumber double dose). The main metabolites, 4-phenoxybenzoic acid and 1-acetyl-2-phenylhydrazine, were not detected in vegetable samples. Other metabolites described by the European Food and Safety Authority, such as IN-JS940 [(2RS)-2-hydroxy-2-(4-phenoxyphenyl)propanoic acid], IN-KF015 [(5RS)-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione] and IN-MN467 [(5RS)-5-methyl-3-[(2-nitrophenyl)amino]-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione], were detected in the three matrices. Untargeted analysis allowed for the putative elucidation of a new metabolite of famoxadone in cucumber (up to 290 μg kg -1 ) and cherry tomato (up to 900 μg kg -1 ) samples.
Conclusion: The dissipation of famoxadone has been investigated in three vegetables: tomato, cucumber and courgette. The persistence of famoxadone was low in the three matrices (DT 50 less than 10 days). Metabolites of famoxadone were monitored, detecting IN-JS940, IN-MN467 and IN-KF015, and the putative elucidation of a new metabolite of famoxadone was performed by applying software tools. © 2019 Society of Chemical Industry.
(© 2019 Society of Chemical Industry.)

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