70-year legacy of the Framingham Heart Study.

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Abstrakt

Tytuł:: 70-year legacy of the Framingham Heart Study.
Autorzy:: Andersson C; Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA. .; Department of Cardiology, Gentofte and Herlev Hospital, Herlev, Denmark. .
Johnson AD; Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Benjamin EJ; Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Preventive Medicine and Cardiology Sections, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Levy D; Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.; Preventive Medicine and Cardiology Sections, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Vasan RS; Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA. .; Preventive Medicine and Cardiology Sections, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA. .; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. .
Źródło:: Nature reviews. Cardiology [Nat Rev Cardiol] 2019 Nov; Vol. 16 (11), pp. 687-698.
Typ publikacji:: Historical Article; Journal Article; Review
Język:: English
Imprint Name(s):: Original Publication: London : Nature Pub. Group
MeSH Terms:: Longitudinal Studies*
Population Surveillance*
Cardiovascular Diseases/*history
Data Collection/*history
Cardiovascular Diseases/epidemiology ; Coronary Artery Disease/epidemiology ; Echocardiography ; Exercise Test ; Genomics ; History, 20th Century ; History, 21st Century ; Humans ; Magnetic Resonance Imaging ; Manometry ; Phenotype ; Risk Factors ; Tomography, X-Ray Computed
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Entry Date(s):: Date Created: 20190509 Date Completed: 20200116 Latest Revision: 20220420
Update Code:: 20240105
DOI:: 10.1038/s41569-019-0202-5
PMID:: 31065045
: Czasopismo naukowe

The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961, seminal work identified major risk factors for CHD (high blood pressure, high cholesterol levels and evidence on the electrocardiogram of left ventricular hypertrophy), which later formed the basis for multivariable 10-year and 30-year risk-prediction algorithms. The FHS cohorts now comprise three generations of participants (n ≈ 15,000) and two minority cohorts. The FHS cohorts are densely phenotyped, with recurring follow-up examinations and surveillance for cardiovascular and non-cardiovascular end points. Assessment of subclinical disease and physiological profiling of these cohorts (with the use of echocardiography, ambulatory electrocardiographic monitoring, exercise stress testing, cardiac CT, heart and brain MRI, serial vascular tonometry and accelerometry) have been performed repeatedly. Over the past decade, the FHS cohorts have undergone deep 'omics' profiling (including whole-genome sequencing, DNA methylation analysis, transcriptomics, high-throughput proteomics and metabolomics, and microbiome studies). The FHS is a rich, longitudinal, transgenerational and deeply phenotyped cohort study with a sustained focus on state-of-the-art epidemiological methods and technological advances to facilitate scientific discoveries.

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