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Tytuł:
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Research progress on the composition and function of parasite-derived exosomes.
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Autorzy:
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Nawaz M; Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Malik MI; Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Hameed M; Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Zhou J; Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China. Electronic address: .
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Źródło:
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Acta tropica [Acta Trop] 2019 Aug; Vol. 196, pp. 30-36. Date of Electronic Publication: 2019 May 06.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Basel.
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MeSH Terms:
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Exosomes/*metabolism
Parasites/*metabolism
Animals ; MicroRNAs ; Proteins/metabolism ; Proteomics ; Transcriptome
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Contributed Indexing:
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Keywords: Cytokines; Excretory-Secretory products; Exosomes; Proteomics; Transcriptomics
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Substance Nomenclature:
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0 (MicroRNAs)
0 (Proteins)
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Entry Date(s):
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Date Created: 20190510 Date Completed: 20191029 Latest Revision: 20191029
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Update Code:
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20240105
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DOI:
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10.1016/j.actatropica.2019.05.004
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PMID:
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31071298
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Parasites use excretory-secretory pathways to communicate with the host. Characterization of exosomes within the excretory-secretory products reveal by which parasites manipulate their hosts. Parasite derived exosomes provide a mechanistic framework for protein and miRNAs transfer. Transcriptomics and proteomics of parasite exosomes identified a large number of miRNAs and proteins being utilized by parasites in their survival, reproduction and development. Characterization of proteins and miRNAs in parasite secreted exosomes provide important information on host-parasite communication and forms the basis for future studies. In this review, we summarize recent advances in isolation and molecular characterization (protein and miRNAs) of parasite derived exosomes.
(Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.)
