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Tytuł:
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Hepatoma-derived growth factor supports the antiapoptosis and profibrosis of pancreatic stellate cells.
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Autorzy:
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Chen YT; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan; Medical Research Department, Chi Mei Medical Center, Tainan, Taiwan.
Chen FW; Institute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chang TH; Institute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wang TW; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Hsu TP; Department of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Chi JY; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Hsiao YW; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Li CF; Medical Research Department, Chi Mei Medical Center, Tainan, Taiwan; Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan. Electronic address: .
Wang JM; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan; International Research Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: .
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Źródło:
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Cancer letters [Cancer Lett] 2019 Aug 10; Vol. 457, pp. 180-190. Date of Electronic Publication: 2019 May 09.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
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Język:
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English
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Imprint Name(s):
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Publication: Limerick : Elsevier Science Ireland
Original Publication: Amsterdam, Elsevier/North-Holland.
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MeSH Terms:
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Apoptosis*/drug effects
Intercellular Signaling Peptides and Proteins/*metabolism
Pancreatic Neoplasms/*metabolism
Pancreatic Stellate Cells/*metabolism
Animals ; CCAAT-Enhancer-Binding Protein-delta/metabolism ; Cell Line, Tumor ; Coculture Techniques ; Fibrosis ; Gene Expression Regulation, Neoplastic ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Intercellular Signaling Peptides and Proteins/pharmacology ; Mice, Inbred NOD ; Mice, SCID ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Pancreatic Stellate Cells/drug effects ; Pancreatic Stellate Cells/pathology ; Signal Transduction ; Transforming Growth Factor beta1/pharmacology ; Tumor Microenvironment
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Contributed Indexing:
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Keywords: And profibrosis; Antiapoptosis; Hepatoma-derived growth factor (HDGF); Pancreatic stellate cells (PSCs)
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Substance Nomenclature:
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0 (CEBPD protein, human)
0 (HIF1A protein, human)
0 (Hypoxia-Inducible Factor 1, alpha Subunit)
0 (Intercellular Signaling Peptides and Proteins)
0 (TGFB1 protein, human)
0 (Transforming Growth Factor beta1)
0 (hepatoma-derived growth factor)
142662-43-9 (CCAAT-Enhancer-Binding Protein-delta)
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Entry Date(s):
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Date Created: 20190513 Date Completed: 20200427 Latest Revision: 20200427
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Update Code:
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20240105
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DOI:
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10.1016/j.canlet.2019.05.001
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PMID:
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31078734
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Pancreatic cancer is refractory and is characterized by extensively surrounding and intratumor fibrotic reactions that are contributed by activated pancreatic stellate cells (PSCs). Herein, we show that CCAAT/enhancer-binding protein δ (CEBPD) responds to transforming growth factor-β1 (TGF-β1) through reciprocal loop regulation and that activated hypoxia inducible factor-1α (HIF-1α) further contributes to the upregulation of the hepatoma-derived growth factor (HDGF) gene. Secreted HDGF contributes to the antiapoptosis of PSCs and consequently leads to the synthesis and deposition of extracellular matrix proteins for stabilizing PSC/pancreatic cancer cell (PCC) tumor foci. This result agrees with the observation that severe stromal growth positively correlated with stromal HDGF and CEBPD expression in pancreatic cancer specimens. Collectively, the identification of the TGF-β1-activated CEBPD/HIF-1α/HDGF axis provides new insights into novel discoveries of HDGF in the antiapoptosis and profibrosis of PSCs and the outgrowth of PCCs.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
