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Tytuł:
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Multiple Cerebral Aneurysms Associated With Neurofibromatosis Type 1.
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Autorzy:
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Takeshima Y; Division of Neurosurgery, Department of Cerebrovascular Medicine and Surgery, Saiseikai Kumamoto Hospital, Kumamoto, Japan.
Kaku Y; Division of Neurosurgery, Department of Cerebrovascular Medicine and Surgery, Saiseikai Kumamoto Hospital, Kumamoto, Japan. Electronic address: .
Nishi T; Division of Neurosurgery, Department of Cerebrovascular Medicine and Surgery, Saiseikai Kumamoto Hospital, Kumamoto, Japan.
Mukasa A; Department of Neurosurgery, Graduate School of Life Sciences, Kumamoto University, Japan.
Yamashiro S; Division of Neurosurgery, Department of Cerebrovascular Medicine and Surgery, Saiseikai Kumamoto Hospital, Kumamoto, Japan.
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Źródło:
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Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2019 Jul; Vol. 28 (7), pp. e83-e91. Date of Electronic Publication: 2019 May 09.
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Typ publikacji:
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Case Reports; Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: Philadelphia, PA : Saunders
Original Publication: New York, NY : Demos Publications, [1991-
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MeSH Terms:
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Aneurysm, Ruptured/*etiology
Intracranial Aneurysm/*etiology
Neurofibromatosis 1/*complications
Aged ; Aneurysm, Ruptured/diagnostic imaging ; Aneurysm, Ruptured/therapy ; Cerebral Angiography/methods ; Computed Tomography Angiography ; Embolization, Therapeutic ; Endovascular Procedures ; Female ; Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/therapy ; Neurofibromatosis 1/diagnosis ; Neurosurgical Procedures ; Risk Factors ; Treatment Outcome
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Contributed Indexing:
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Keywords: Multiple cerebral aneurysms; neurofibromatosis type 1; subarachnoid hemorrhage; therapeutic indication
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Entry Date(s):
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Date Created: 20190514 Date Completed: 20190624 Latest Revision: 20190624
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Update Code:
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20240105
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DOI:
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10.1016/j.jstrokecerebrovasdis.2019.04.019
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PMID:
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31080139
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Neurofibromatosis type 1 (NF1) is a rare disease with an incidence of approximately one in every 3000 births. NF1 is mainly recognized as a tumor suppressor. Vasculopathy in NF1 is well described in the literature, but the association between NF1 and cerebral aneurysm has not been determined. We report a case of a 67-year-old female with NF1 accompanied by 8 cerebral aneurysms. Two of the patient's unruptured aneurysms, the large distal anterior cerebral artery (ACA) aneurysm and anterior communicating artery aneurysm, were initially treated with microsurgical clipping. The peripheral ACA aneurysm gradually increased in size and ruptured after 5 years. Coil embolization was performed for the ruptured aneurysm. Four of the 5 remaining unruptured aneurysms were treated surgically. The patient is currently well, without neurological deficit, and coil embolization is scheduled for the last remaining aneurysm. NF1 is a probable risk factor for multiple cerebral aneurysms due to vessel wall vulnerability. Therapeutic indications for patients with NF1 who show multiple cerebral aneurysms include strict follow-up and aggressive treatment to avoid subarachnoid hemorrhage.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
