Fabrication and Characterisation of Stimuli Responsive Piezoelectric PVDF and Hydroxyapatite-Filled PVDF Fibrous Membranes.

Tytuł:: Fabrication and Characterisation of Stimuli Responsive Piezoelectric PVDF and Hydroxyapatite-Filled PVDF Fibrous Membranes.
Autorzy:: Tandon B; School of Materials, MSS Tower, The University of Manchester, Manchester M13 9PL, UK. .; Bio-Active Materials Group, School of Materials, MSS Tower, The University of Manchester, Manchester M13 9PL, UK. .
Kamble P; School of Materials, MSS Tower, The University of Manchester, Manchester M13 9PL, UK. .
Olsson RT; Department of Fibre and Polymer Technology, School of Chemical Science and Engineering, KTH Royal Institute of Technology, Teknikringen 56, SE-10044 Stockholm, Sweden. .
Blaker JJ; School of Materials, MSS Tower, The University of Manchester, Manchester M13 9PL, UK. .; Bio-Active Materials Group, School of Materials, MSS Tower, The University of Manchester, Manchester M13 9PL, UK. .
Cartmell SH; School of Materials, MSS Tower, The University of Manchester, Manchester M13 9PL, UK. .
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2019 May 17; Vol. 24 (10). Date of Electronic Publication: 2019 May 17.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI, c1995-
MeSH Terms:: Biocompatible Materials/*chemical synthesis
Durapatite/*chemistry
Polyvinyls/*chemistry
Biocompatible Materials/chemistry ; Tissue Engineering ; Wettability
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Grant Information:: EP/I02249X/1 Engineering and Physical Sciences Research Council
Contributed Indexing:: Keywords: electrospinning; piezoelectric; poly(vinylidene fluoride); solution blow spinning; surface roughness; tissue repair; wettability
Substance Nomenclature:: 0 (Biocompatible Materials)
0 (Polyvinyls)
24937-79-9 (polyvinylidene fluoride)
91D9GV0Z28 (Durapatite)
Entry Date(s):: Date Created: 20190522 Date Completed: 20191115 Latest Revision: 20231012
Update Code:: 20240104
PubMed Central ID:: PMC6571942
DOI:: 10.3390/molecules24101903
PMID:: 31108899
: Czasopismo naukowe

Pełny tekst

Poly(vinylidene fluoride) has attracted interest from the biomaterials community owing to its stimuli responsive piezoelectric property and promising results for application in the field of tissue engineering. Here, solution blow spinning and electrospinning were employed to fabricate PVDF fibres and the variation in resultant fibre properties assessed. The proportion of piezoelectric β-phase in the solution blow spun fibres was higher than electrospun fibres. Fibre production rate was circa three times higher for solution blow spinning compared to electrospinning for the conditions explored. However, the solution blow spinning method resulted in higher fibre variability between fabricated batches. Fibrous membranes are capable of generating different cellular response depending on fibre diameter. For this reason, electrospun fibres with micron and sub-micron diameters were fabricated, along with successful inclusion of hydroxyapatite particles to fabricate stimuli responsive bioactive fibres.

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