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Tytuł:
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The sarcoplasmic reticulum and SERCA: a nexus for muscular adaptive thermogenesis.
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Autorzy:
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Gamu D; Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.; Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Juracic ES; Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.; Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Hall KJ; Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.; Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Tupling AR; Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.; Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
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Źródło:
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Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [Appl Physiol Nutr Metab] 2020 Jan; Vol. 45 (1), pp. 1-10. Date of Electronic Publication: 2019 May 22.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: 2011- : Ottawa, ON : Canadian Science Publishing
Original Publication: Ottawa, ON : National Research Council of Canada, c2006-
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MeSH Terms:
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Sarcoplasmic Reticulum*/enzymology
Sarcoplasmic Reticulum*/metabolism
Sarcoplasmic Reticulum*/physiology
Sarcoplasmic Reticulum Calcium-Transporting ATPases*
Thermogenesis/*physiology
Animals ; Humans ; Mice ; Models, Biological ; Muscle, Skeletal/physiology
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Contributed Indexing:
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Keywords: body mass maintenance; energy balance; fonction des muscles squelettiques; maintien de la masse corporelle; muscle physiology; métabolisme des muscles squelettiques; obesity; obésité; physiologie musculaire; skeletal muscle function; skeletal muscle metabolism; équilibre énergétique
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Substance Nomenclature:
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EC 3.6.3.8 (Sarcoplasmic Reticulum Calcium-Transporting ATPases)
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Entry Date(s):
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Date Created: 20190523 Date Completed: 20200617 Latest Revision: 20200617
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Update Code:
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20240104
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DOI:
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10.1139/apnm-2019-0067
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PMID:
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31116956
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We are currently facing an "obesity epidemic" worldwide. Promoting inefficient metabolism in muscle represents a potential treatment for obesity and its complications. Sarco(endo)plasmic reticulum (SR) Ca 2+ -ATPase (SERCA) pumps in muscle are responsible for maintaining low cytosolic Ca 2+ concentration through the ATP-dependent pumping of Ca 2+ from the cytosol into the SR lumen. SERCA activity has the potential to be a critical regulator of body mass and adiposity given that it is estimated to contribute upwards of 20% of daily energy expenditure. More interestingly, this fraction can be modified physiologically in the face of stressors, such as ambient temperature and diet, through its physical interaction with several regulators known to inhibit Ca 2+ uptake and muscle function. In this review, we discuss advances in our understanding of Ca 2+ -cycling thermogenesis within skeletal muscle, focusing on SERCA and its protein regulators, which were thought previously to only modulate muscular contractility. Novelty ATP consumption by SERCA pumps comprises a large proportion of resting energy expenditure in muscle and is dynamically regulated through interactions with small SERCA regulatory proteins. SERCA efficiency correlates significantly with resting metabolism, such that individuals with a higher resting metabolic rate have less energetically efficient SERCA Ca 2+ pumping in muscle (i.e., lower coupling ratio). Futile Ca 2+ cycling is a versatile heat generating mechanism utilized by both skeletal muscle and beige fat.
