Infection caused by Klebsiella pneumoniae ST11 in a patient after craniectomy.

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Abstrakt

Tytuł:: Infection caused by Klebsiella pneumoniae ST11 in a patient after craniectomy.
Autorzy:: Ojdana D; Department of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, 15a Waszyngtona Street, 15-269, Bialystok, Poland. .
Kochanowicz J; Department of Neurosurgery, University Hospital of Bialystok, 24a M. Sklodowskiej-Cure Street, 15-276, Bialystok, Poland.
Sacha P; Department of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, 15a Waszyngtona Street, 15-269, Bialystok, Poland.
Sieńko A; Department of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, 15a Waszyngtona Street, 15-269, Bialystok, Poland.
Wieczorek P; Department of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, 15a Waszyngtona Street, 15-269, Bialystok, Poland.
Majewski P; Department of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, 15a Waszyngtona Street, 15-269, Bialystok, Poland.
Hauschild T; Department of Microbiology, Institute of Biology, University of Bialystok, 1J Ciolkowskiego Street, 15-245, Bialystok, Poland.
Mariak Z; Department of Neurosurgery, University Hospital of Bialystok, 24a M. Sklodowskiej-Cure Street, 15-276, Bialystok, Poland.
Tryniszewska E; Department of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, 15a Waszyngtona Street, 15-269, Bialystok, Poland.
Źródło:: Folia microbiologica [Folia Microbiol (Praha)] 2020 Feb; Vol. 65 (1), pp. 205-209. Date of Electronic Publication: 2019 May 22.
Typ publikacji:: Case Reports; Journal Article
Język:: English
Imprint Name(s):: Publication: New York : Springer
Original Publication: Praha, Academia Scientiarum Bohemoslovenica.
MeSH Terms:: Drug Resistance, Multiple, Bacterial*
Anti-Bacterial Agents/*pharmacology
Craniotomy/*adverse effects
Klebsiella Infections/*diagnostic imaging
Klebsiella pneumoniae/*drug effects
Anti-Bacterial Agents/therapeutic use ; Bacterial Typing Techniques ; Electrophoresis, Gel, Pulsed-Field ; Fatal Outcome ; Humans ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/classification ; Klebsiella pneumoniae/enzymology ; Male ; Microbial Sensitivity Tests ; Multilocus Sequence Typing ; Tomography, X-Ray Computed ; Young Adult ; beta-Lactamases/genetics
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Grant Information:: N/ST/ZB/15/006/2222 Uniwersytet Medyczny w Bialymstoku
Substance Nomenclature:: 0 (Anti-Bacterial Agents)
EC 3.5.2.6 (beta-Lactamases)
Entry Date(s):: Date Created: 20190524 Date Completed: 20200928 Latest Revision: 20200928
Update Code:: 20240104
PubMed Central ID:: PMC6971140
DOI:: 10.1007/s12223-019-00718-y
PMID:: 31119589
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Klebsiella pneumoniae infections have always been an important problem in public health, but today, the increasing resistance of these bacteria to antibiotics due to β-lactamases production has renewed interest in K. pneumoniae infections. The aim of the study was to present a case of a neurosurgical patient with multidrug-resistant K. pneumoniae ST11 infection after craniectomy. Four K. pneumoniae isolates from various clinical materials of the patient undergone identification and susceptibility testing with the Vitek2 system. Tests for β-lactamases production were performed according to EUCAST guidelines. Strains were analyzed for bla genes responsible for β-lactamase production (bla TEM , bla SHV , bla CTX-M , bla VIM , bla IMP , bla NDM , bla KPC , bla OXA-48 ) using PCR. Moreover, the genetic relatedness of these isolates was determined by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). All tested strain presented multidrug resistance. The highest susceptibility was observed for imipenem, meropenem, and ertapenem. The strain isolated from the nervous system was ESBL-positive with bla SHV-11 , bla TEM-1 , and bla CTX-M-15 genes. Additionally, the strain from urine was bla KPC-3 -positive. Molecular typing revealed that all strains belonged to the same clone and identified two PFGE profiles. The analysis of MLST allelic profile showed that tested K. pneumoniae strains belonged to ST11. Identification of ST11 K. pneumoniae as etiological factor of infection unfavorably impacts on prognosis among neurosurgical patient after craniectomy.

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