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Tytuł pozycji:

Domino Multicomponent Approach for the Synthesis of Functionalized Spiro-Indeno[1,2- b ]quinoxaline Heterocyclic Hybrids and Their Antimicrobial Activity, Synergistic Effect and Molecular Docking Simulation.

Tytuł :
Domino Multicomponent Approach for the Synthesis of Functionalized Spiro-Indeno[1,2- b ]quinoxaline Heterocyclic Hybrids and Their Antimicrobial Activity, Synergistic Effect and Molecular Docking Simulation.
Autorzy :
Almansour AI; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. .
Arumugam N; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. .
Suresh Kumar R; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. .
Al-Thamili DM; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. .
Periyasami G; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. .
Ponmurugan K; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. .
Al-Dhabi NA; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. .
Perumal K; Department of Chemistry and Biochemistry, The Ohio State University, 151 W. Woodruff Ave, Columbus, OH 43210, USA. .
Premnath D; Department of Bioscience and Technology, Karunya Institute of Technology and Science, Branch of Bioinformatics, School of Agriculture and Biosciences, Karunya Nagar, Coimbatore-641114, India. .
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2019 May 22; Vol. 24 (10). Date of Electronic Publication: 2019 May 22.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Basel, Switzerland : MDPI, c1995-
MeSH Terms :
Anti-Bacterial Agents/*chemical synthesis
Anti-Bacterial Agents/*pharmacology
Quinoxalines/*chemical synthesis
Quinoxalines/*pharmacology
Anti-Bacterial Agents/chemistry ; Cycloaddition Reaction ; Drug Synergism ; Escherichia coli/drug effects ; Imidazoles/chemistry ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Structure ; Quinoxalines/chemistry ; Streptomycin/pharmacology ; Structure-Activity Relationship ; Vancomycin/pharmacology
References :
J Med Chem. 2001 Feb 15;44(4):586-93. (PMID: 11170648)
EMBO J. 2003 Jul 1;22(13):3199-209. (PMID: 12839983)
J Antimicrob Chemother. 2008 Jun;61(6):1295-301. (PMID: 18339637)
Eur J Med Chem. 2010 Jan;45(1):411-22. (PMID: 19850377)
Bioorg Med Chem Lett. 2010 Jun 15;20(12):3698-702. (PMID: 20483609)
Eur J Med Chem. 2011 Feb;46(2):600-7. (PMID: 21177001)
Eur J Med Chem. 2012 May;51:79-91. (PMID: 22405285)
Bioorg Med Chem Lett. 2012 Dec 15;22(24):7588-92. (PMID: 23116886)
Bioorg Med Chem Lett. 2013 May 15;23(10):2979-83. (PMID: 23570788)
Bioorg Med Chem Lett. 2013 Jul 1;23(13):3954-8. (PMID: 23673015)
Med Res Rev. 2014 Mar;34(2):340-437. (PMID: 23740514)
Eur J Med Chem. 2014 Mar 3;74:50-64. (PMID: 24445312)
Bioorg Med Chem Lett. 2014 Apr 1;24(7):1815-9. (PMID: 24594354)
Eur J Med Chem. 2014 Apr 22;77:315-22. (PMID: 24657568)
Eur J Med Chem. 2015 Jun 5;97:673-98. (PMID: 24994707)
Bioorg Med Chem Lett. 2015 Jan 15;25(2):389-99. (PMID: 25435149)
J Org Chem. 2015 Mar 20;80(6):3187-94. (PMID: 25714116)
Interdiscip Sci. 2017 Mar;9(1):130-139. (PMID: 26725054)
J Med Chem. 2016 May 12;59(9):4087-102. (PMID: 26878596)
Expert Opin Drug Discov. 2016 Sep;11(9):831-4. (PMID: 27233084)
Bioorg Chem. 2018 Sep;79:64-71. (PMID: 29723743)
Molecules. 2018 May 05;23(5):null. (PMID: 29734741)
Grant Information :
Deanship of Scientific Research at King Saudi University for the Research grant RGP-026. Deanship of Scientific Research, King Saud University
Contributed Indexing :
Keywords: antimicrobial activity; dispiropyrrolidine; docking studies; domino multicomponent reaction; indeno[1,2-b]quinoxaline; synergistic effect
Substance Nomenclature :
0 (Anti-Bacterial Agents)
0 (Imidazoles)
0 (Quinoxalines)
41PS77334A (1-butyl-3-methylimidazolium chloride)
6Q205EH1VU (Vancomycin)
Y45QSO73OB (Streptomycin)
Entry Date(s) :
Date Created: 20190525 Date Completed: 20191125 Latest Revision: 20200225
Update Code :
20210210
PubMed Central ID :
PMC6572414
DOI :
10.3390/molecules24101962
PMID :
31121813
Czasopismo naukowe
An expedient synthesis of hitherto unexplored novel hybrid heterocycles comprising dispiropyrrolidine, N -styrylpiperidone and indeno[1,2- b ]quinoxaline units has been developed via domino multicomponent 1,3-dipolar cycloaddition strategy employing a new class of azomethine ylide in ionic liquid, 1-butyl-3-methylimidazolium bromide. This domino protocol involves, 1,3-dipolar cycloaddition and concomitant enamine reaction affording the dispiropyrrolidine tethered N -styrylpiperidone hybrid heterocycles in moderate to good yield in a single step. These compounds were evaluated for their antimicrobial activity against bacterial and fungal pathogens, therein compounds 8f , 8h , and 8l displayed significant activity against tested microbial pathogens. The synergistic effect revealed that the combination of compound 8h with streptomycin and vancomycin exhibited potent synergistic activity against E. coli ATCC 25922. In addition, molecular docking simulation has also been studied for the most active compound.
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