Transformed mucosa-associated lymphoid tissue lymphomas: A single institution retrospective study including polymerase chain reaction-based clonality analysis.

Szczegóły
Abstrakt

Tytuł:: Transformed mucosa-associated lymphoid tissue lymphomas: A single institution retrospective study including polymerase chain reaction-based clonality analysis.
Autorzy:: Kiesewetter B; Department of Medicine I, Clinical Division of Oncology, Medical University of Vienna, Vienna, Austria.
Lamm W; Department of Medicine I, Clinical Division of Oncology, Medical University of Vienna, Vienna, Austria.
Dolak W; Department of Medicine III, Clinical Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.
Lukas J; Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
Mayerhoefer ME; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Weber M; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Schiefer AI; Department of Pathology, Medical University of Vienna, Vienna, Austria.
Kornauth C; Department of Pathology, Medical University of Vienna, Vienna, Austria.
Bayer G; Department of Pathology, Medical University of Vienna, Vienna, Austria.
Simonitsch-Klupp I; Department of Pathology, Medical University of Vienna, Vienna, Austria.
Raderer M; Department of Medicine I, Clinical Division of Oncology, Medical University of Vienna, Vienna, Austria.
Źródło:: British journal of haematology [Br J Haematol] 2019 Aug; Vol. 186 (3), pp. 448-459. Date of Electronic Publication: 2019 May 24.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Oxford : Wiley-Blackwell
Original Publication: Oxford : Blackwell Scientific Publications
MeSH Terms:: Lymphoma, B-Cell, Marginal Zone/*pathology
Polymerase Chain Reaction/*methods
Adult ; Aged ; Aged, 80 and over ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Young Adult
References:: Oncologist. 2015 Aug;20(8):915-25. (PMID: 26156327)
Blood. 2017 Sep 21;130(12):1409-1417. (PMID: 28720586)
Blood. 2001 Jul 1;98(1):238-40. (PMID: 11418487)
Int J Cancer. 2013 Feb 1;132(3):E116-27. (PMID: 22890838)
Am J Pathol. 1990 May;136(5):1153-64. (PMID: 2349966)
Genes Chromosomes Cancer. 2001 Aug;31(4):316-25. (PMID: 11433522)
CA Cancer J Clin. 2016 Mar-Apr;66(2):153-71. (PMID: 26773441)
J Clin Pathol. 2000 Mar;53(3):187-90. (PMID: 10823136)
Gut Liver. 2018 May 15;12(3):278-287. (PMID: 29409307)
Br J Haematol. 2016 Sep;174(6):923-31. (PMID: 27460179)
J Clin Oncol. 2007 Jun 10;25(17):2426-33. (PMID: 17485708)
J Clin Oncol. 2011 May 10;29(14):1827-34. (PMID: 21483014)
Am J Clin Pathol. 2013 Jul;140(1):114-26. (PMID: 23765542)
J Clin Pathol. 2007 Apr;60(4):361-72. (PMID: 16950858)
J Clin Oncol. 2006 Jul 1;24(19):3136-41. (PMID: 16769982)
F1000Res. 2018 Mar 28;7:406. (PMID: 29657712)
Leukemia. 2003 Dec;17(12):2257-317. (PMID: 14671650)
Blood. 1995 Dec 15;86(12):4587-93. (PMID: 8541549)
Blood. 2009 Apr 9;113(15):3553-7. (PMID: 19202129)
Ann Hematol. 2009 May;88(5):417-24. (PMID: 18777110)
Blood. 2003 Apr 1;101(7):2489-95. (PMID: 12456507)
Bone Marrow Transplant. 2013 Mar;48(3):452-8. (PMID: 23208313)
Ann Oncol. 2014 Jan;25(1):210-5. (PMID: 24356632)
Sci Rep. 2017 Jul 20;7(1):5963. (PMID: 28729720)
Gastroenterology. 1997 Jun;112(6):1871-5. (PMID: 9178679)
Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10209-13. (PMID: 10954754)
Ann Oncol. 2015 Nov;26(11):2329-35. (PMID: 26400898)
Br J Haematol. 2013 Jan;160(1):47-52. (PMID: 23043300)
J Clin Oncol. 2017 Jun 10;35(17):1905-1912. (PMID: 28355112)
Immunol Rev. 1998 Apr;162:261-80. (PMID: 9602370)
Blood. 2017 Oct 12;130(15):1772-1774. (PMID: 28801448)
Leukemia. 2004 Jun;18(6):1102-7. (PMID: 15085149)
Cancer. 2013 Feb 1;119(3):629-38. (PMID: 22893605)
Leukemia. 1996 Jul;10(7):1190-7. (PMID: 8684001)
Gastroenterol Res Pract. 2015;2015:102656. (PMID: 25922601)
Ann Oncol. 2017 May 1;28(5):1064-1069. (PMID: 28327924)
Curr Opin Oncol. 2013 Sep;25(5):470-9. (PMID: 23942292)
Contributed Indexing:: Keywords: MALT lymphoma; clonality analysis; diffuse large B-cell lymphoma; histological transformation; indolent lymphoma
Entry Date(s):: Date Created: 20190525 Date Completed: 20200707 Latest Revision: 20200707
Update Code:: 20240104
PubMed Central ID:: PMC6771836
DOI:: 10.1111/bjh.15953
PMID:: 31124124
: Czasopismo naukowe

Full Text Finder

Given the lack of consistent data regarding the clinico-pathological features and clonal lymphomagenesis of patients with mucosa-associated lymphoid tissue (MALT) lymphoma and histological transformation (HT), we have systematically analysed 379 patients (32% gastric, 68% extra-gastric; median follow-up 52 months) diagnosed with HT at the Medical University Vienna 1999-2017, and reassessed tissues of identified patients by polymerase chain reaction (PCR)-based clonality analysis. HT was documented in 12/379 patients (3·2%) and occurred at a median time of 22 months (range; 6-202 months) after diagnosis of MALT lymphoma. By PCR-based clonality analysis, we detected a clear-cut clonal relationship of MALT lymphoma and diffuse large B-cell lymphoma (DLBCL) in 8 of 11 analysed cases proving that the large majority of DLBCL following MALT lymphoma are clonally-related and constitute a real transformation. Interestingly, HT occurred within the first 2·5 years after diagnosis in patients with clonal relationship, whereas time to aggressive lymphoma was longer in patients identified as clonally-unrelated (most likely secondary) lymphoma (82-202 months), suggesting that HT is an early event in this disease. Survival of patients with HT was poor with 6/12 dying at 1·5-33 months after HT, however, patients with localized gastric transformation had a superior outcome with only 1/6 dying due to progression of lymphoma.
(© 2019 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.)

Informacja