Relationship of auditory electrophysiological responses to magnetic resonance spectroscopy metabolites in Early Phase Psychosis.

Szczegóły
Abstrakt

Tytuł:: Relationship of auditory electrophysiological responses to magnetic resonance spectroscopy metabolites in Early Phase Psychosis.
Autorzy:: Bartolomeo LA; Department of Psychological and Brain Sciences and Program in Neuroscience, Indiana University, Bloomington, IN, United States of America.
Wright AM; School of Health Sciences, Purdue University, Lafayette, IN, United States of America.
Ma RE; School of Health Sciences, Purdue University, Lafayette, IN, United States of America; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States of America.
Hummer TA; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States of America; Department of Psychiatry, Prevention and the Recovery Center for Early Psychosis, Indiana University School of Medicine, Indianapolis, IN, United States of America.
Francis MM; Department of Psychiatry, Prevention and the Recovery Center for Early Psychosis, Indiana University School of Medicine, Indianapolis, IN, United States of America.
Visco AC; Department of Psychiatry, Prevention and the Recovery Center for Early Psychosis, Indiana University School of Medicine, Indianapolis, IN, United States of America.
Mehdiyoun NF; Department of Psychiatry, Prevention and the Recovery Center for Early Psychosis, Indiana University School of Medicine, Indianapolis, IN, United States of America.
Bolbecker AR; Department of Psychological and Brain Sciences and Program in Neuroscience, Indiana University, Bloomington, IN, United States of America.
Hetrick WP; Department of Psychological and Brain Sciences and Program in Neuroscience, Indiana University, Bloomington, IN, United States of America.
Dydak U; School of Health Sciences, Purdue University, Lafayette, IN, United States of America; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States of America.
Barnard J; Section of Biostatistics, Cleveland Clinic, Cleveland, OH, United States of America.
O'Donnell BF; Department of Psychological and Brain Sciences and Program in Neuroscience, Indiana University, Bloomington, IN, United States of America. Electronic address: .
Breier A; Department of Psychiatry, Prevention and the Recovery Center for Early Psychosis, Indiana University School of Medicine, Indianapolis, IN, United States of America.
Źródło:: International journal of psychophysiology : official journal of the International Organization of Psychophysiology [Int J Psychophysiol] 2019 Nov; Vol. 145, pp. 15-22. Date of Electronic Publication: 2019 May 23.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Amsterdam ; New York : Elsevier, [c1983-
MeSH Terms:: Cerebral Cortex/*physiopathology
Evoked Potentials, Auditory/*physiology
Psychotic Disorders/*physiopathology
Adolescent ; Adult ; Cerebral Cortex/metabolism ; Electroencephalography ; Female ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Psychotic Disorders/metabolism ; Young Adult
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Grant Information:: R01 MH074983 United States MH NIMH NIH HHS; R21 MH091774 United States MH NIMH NIH HHS
Contributed Indexing:: Keywords: Auditory steady state response; Event-related potentials; Magnetic resonance spectroscopy; Mismatch negativity; Psychosis; Schizophrenia
Entry Date(s):: Date Created: 20190527 Date Completed: 20200525 Latest Revision: 20210109
Update Code:: 20240104
PubMed Central ID:: PMC6791740
DOI:: 10.1016/j.ijpsycho.2019.05.009
PMID:: 31129143
: Czasopismo naukowe

Both auditory evoked responses and metabolites measured by magnetic resonance spectroscopy (MRS) are altered in schizophrenia and other psychotic disorders, but the relationship between electrophysiological and metabolic changes are not well characterized. We examined the relation of MRS metabolites to cognitive and electrophysiological measures in individuals during the early phase of psychosis (EPP) and in healthy control subjects. The mismatch negativity (MMN) of the auditory event-related potential to duration deviant tones and the auditory steady response (ASSR) to 40 Hz stimulation were assessed. MRS was used to quantify glutamate+glutamine (Glx), N-Acetylasparate (NAA), creatine (Cre), myo-inositol (Ins) and choline (Cho) at a voxel placed medially in the frontal cortex. MMN amplitude and ASSR power did not differ between groups. The MRS metabolites Glx, Cre and Cho were elevated in the psychosis group. Partial least squares analysis in the patient group indicated that elevated levels of MRS metabolites were associated with reduced MMN amplitude and increased 40 Hz ASSR power. There were no correlations between the neurobiological measures and clinical measures. These data suggest that elevated neurometabolites early in psychosis are accompanied by altered auditory neurotransmission, possibly indicative of a neuroinflammatory or excitotoxic disturbance which disrupts a wide range of metabolic processes in the cortex.
(Copyright © 2019 Elsevier B.V. All rights reserved.)

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