Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

Histological assessment of stromal maturity as a prognostic factor in surgically treated gastric adenocarcinoma.

Tytuł:
Histological assessment of stromal maturity as a prognostic factor in surgically treated gastric adenocarcinoma.
Autorzy:
Kemi NA; Cancer and Translational Medicine Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.
Eskuri M; Cancer and Translational Medicine Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.
Pohjanen VM; Cancer and Translational Medicine Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.
Karttunen TJ; Cancer and Translational Medicine Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.
Kauppila JH; Cancer and Translational Medicine Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Źródło:
Histopathology [Histopathology] 2019 Dec; Vol. 75 (6), pp. 882-889. Date of Electronic Publication: 2019 Oct 14.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Oxford, Blackwell Scientific Publications.
MeSH Terms:
Adenocarcinoma/*diagnosis
Stomach Neoplasms/*diagnosis
Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Cohort Studies ; Feasibility Studies ; Female ; Finland ; Humans ; Kaplan-Meier Estimate ; Male ; Prognosis ; Proportional Hazards Models ; Reproducibility of Results ; Retrospective Studies ; Stomach/pathology ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Stromal Cells/pathology
References:
Bray F, Ferlay J, Soerjomataram I et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018; 68; 394-424.
Orditura M, Galizia G, Sforza V et al. Treatment of gastric cancer. World J. Gastroenterol. 2014; 20; 1635-1649.
Sano T, Coit DG, Kim HH et al. Proposal of a new stage grouping of gastric cancer for TNM classification: International Gastric Cancer Association staging project. Gastric Cancer 2017; 20; 217-225.
Kalluri R. The biology and function of fibroblasts in cancer. Nat. Rev. Cancer 2016; 16; 582-598.
Ueno H, Kanemitsu Y, Sekine S et al. Desmoplastic pattern at the tumor front defines poor-prognosis subtypes of colorectal cancer. Am. J. Surg. Pathol. 2017; 41; 1506-1512.
Ueno H, Sekine S, Oshiro T et al. Disentangling the prognostic heterogeneity of stage III colorectal cancer through histologic stromal categorization. Surgery 2018; 163; 777-783.
Ueno H, Jones A, Jass JR et al. Clinicopathological significance of the ‘keloid-like’ collagen and myxoid stroma in advanced rectal cancer. Histopathology 2002; 40; 327-334.
Zhou ZH, Ji CD, Xiao HL et al. Reorganized collagen in the tumor microenvironment of gastric cancer and its association with prognosis. J. Cancer 2017; 8; 1466-1476.
Kemi N, Eskuri M, Herva A et al. Tumour-stroma ratio and prognosis in gastric adenocarcinoma. Br. J. Cancer 2018; 119; 435-439.
Kemi N, Eskuri M, Ikalainen J et al. Tumor budding and prognosis in gastric adenocarcinoma. Am. J. Surg. Pathol. 2019; 43; 229-234.
Official Statistics of Finland (OSF) (OSF website). Quality description: causes of death 2017. 2018. Available at: https://www.stat.fi/til/ksyyt/2017/ksyyt_2017_2018-12-17_laa_001_en.html (accessed 7 January 2019).
Langer R, Becker K. Tumor regression grading of gastrointestinal cancers after neoadjuvant therapy. Virchows Arch. 2018; 472; 175-186.
Ueno H, Jones AM, Wilkinson KH et al. Histological categorisation of fibrotic cancer stroma in advanced rectal cancer. Gut 2004; 53; 581-586.
Ueno H, Konishi T, Ishikawa Y et al. Histologic categorization of fibrotic cancer stroma in the primary tumor is an independent prognostic index in resectable colorectal liver metastasis. Am. J. Surg. Pathol. 2014; 38; 1380-1386.
Ueno H, Shinto E, Kajiwara Y et al. Prognostic impact of histological categorisation of epithelial-mesenchymal transition in colorectal cancer. Br. J. Cancer 2014; 111; 2082-2090.
Ueno H, Shinto E, Shimazaki H et al. Histologic categorization of desmoplastic reaction: its relevance to the colorectal cancer microenvironment and prognosis. Ann. Surg. Oncol. 2015; 22; 1504-1512.
Huang L, Xu AM, Liu S et al. Cancer-associated fibroblasts in digestive tumors. World J. Gastroenterol. 2014; 20; 17804-17818.
Alexander J, Cukierman E. Stromal dynamic reciprocity in cancer: intricacies of fibroblastic-ECM interactions. Curr. Opin. Cell Biol. 2016; 42; 80-93.
Nieto MA, Huang RY, Jackson RA et al. EMT: 2016. Cell 2016; 166; 21-45.
Erdogan B, Webb DJ. Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis. Biochem. Soc. Trans. 2017; 45; 229-236.
Pandol S, Edderkaoui M, Gukovsky I et al. Desmoplasia of pancreatic ductal adenocarcinoma. Clin. Gastroenterol. Hepatol. 2009; 7; S44-S47.
Drifka CR, Loeffler AG, Mathewson K et al. Highly aligned stromal collagen is a negative prognostic factor following pancreatic ductal adenocarcinoma resection. Oncotarget 2016; 7; 76197-76213.
Nebuloni M, Albarello L, Andolfo A et al. Insight on colorectal carcinoma infiltration by studying perilesional extracellular matrix. Sci. Rep. 2016; 6; 22522.
Grant Information:
Orionin Tutkimussäätiö; Sigrid Juséliuksen Säätiö; Thelma Mäkikyrö Foundation; Mary and Georg C. Ehrnrooth Foundation; Finnish Cancer Foundation; Vatsatautien Tutkimusäätiö
Contributed Indexing:
Keywords: collagen; gastric cancer; prognosis; stroma
Entry Date(s):
Date Created: 20190608 Date Completed: 20200427 Latest Revision: 20200427
Update Code:
20240105
DOI:
10.1111/his.13934
PMID:
31173384
Czasopismo naukowe
Aims: Histological assessment of stromal maturity is a potential prognostic factor in colorectal cancer, but its applicability in gastric adenocarcinoma is completely unknown. The aim of this study was to evaluate the feasibility and prognostic significance of assessing stromal maturity in gastric adenocarcinoma.
Methods and Results: This study was conducted retrospectively in a cohort of 583 gastric adenocarcinoma patients treated surgically in Oulu University Hospital, Finland between 1983 and 2016. The original diagnostic slides were used for assessment of stromal maturity. Patients were divided into mature stroma and immature stroma groups, and stromal maturity was analysed in relation to 5-year and overall survival (OS). The primary outcome of the study was 5-year survival, and the secondary outcome was OS. The kappa-coefficient for interobserver agreement was 0.609. Patients with immature stroma had worse 5-year survival compared to patients with mature stroma [adjusted hazard ratio (HR) = 1.32, 95% confidence interval (CI) = 1.06-1.64]. Stromal maturity was significantly associated with 5-year survival in intestinal-type subgroup (adjusted HR = 0.63, 95% CI = 1.20-2.21), but not in the diffuse-type subgroup (adjusted HR = 1.21, 95% CI = 0.87-1.70).
Conclusions: Stromal maturity is an independent prognostic factor in gastric adenocarcinoma, and it can be analysed with moderate reproducibility.
(© 2019 John Wiley & Sons Ltd.)
Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies