Changes in molecular epidemiology and antimicrobial resistance profiles of Clostridioides (Clostridium) difficile strains in the United States between 2011 and 2017.

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Tytuł:: Changes in molecular epidemiology and antimicrobial resistance profiles of Clostridioides (Clostridium) difficile strains in the United States between 2011 and 2017.
Autorzy:: Tickler IA; Cepheid, Sunnyvale, CA, United States. Electronic address: .
Obradovich AE; Creighton University School of Medicine, Omaha, NE, United States.
Goering RV; Creighton University School of Medicine, Omaha, NE, United States.
Fang FC; University of Washington School of Medicine, Seattle, WA, United States.
Tenover FC; Cepheid, Sunnyvale, CA, United States.
Corporate Authors:: HAI Consortium
Źródło:: Anaerobe [Anaerobe] 2019 Dec; Vol. 60, pp. 102050. Date of Electronic Publication: 2019 Jun 04.
Typ publikacji:: Historical Article; Journal Article
Język:: English
Imprint Name(s):: Publication: London : Academic Press
Original Publication: London ; San Diego : Academic Press, c1995-
MeSH Terms:: Drug Resistance, Bacterial*
Molecular Epidemiology*
Anti-Bacterial Agents/*pharmacology
Clostridioides difficile/*drug effects
Clostridioides difficile/*genetics
Clostridium Infections/*epidemiology
Clostridium Infections/*microbiology
Anti-Bacterial Agents/therapeutic use ; Clostridioides difficile/classification ; Clostridium Infections/history ; History, 21st Century ; Humans ; Microbial Sensitivity Tests ; Polymerase Chain Reaction ; Public Health Surveillance ; Ribotyping ; United States/epidemiology
Contributed Indexing:: Keywords: Antimicrobial susceptibility; Clostridioides difficile; Clostridium difficile; PCR ribotypes
Substance Nomenclature:: 0 (Anti-Bacterial Agents)
Entry Date(s):: Date Created: 20190608 Date Completed: 20200420 Latest Revision: 20201209
Update Code:: 20240104
DOI:: 10.1016/j.anaerobe.2019.06.003
PMID:: 31173889
: Czasopismo naukowe

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PCR ribotyping and antimicrobial susceptibility testing were used to characterize 940 Clostridioides (Clostridium) difficile isolates collected from 26 U S. hospitals over three time periods from 2011 to 2017. The proportion of ribotype (RT) 027 isolated during the three surveys decreased significantly over time from 31% in 2011-2012, to 22% in 2013-2014, and to 14% in 2015-2017 (p < 0.001 and p = 0.010, respectively), while we observed an increase in prevalence of RT106, that rose from 7% in our first survey to 19% of isolates in our last survey (p < 0.001). In addition, both RT056 and RT002 rose from 3% to 10% (p < 0.001). The proportions of all other ribotypes remained steady over time, and RT014/020 was the third most common strain type in our convenience sample in the final survey. Overall, resistance to moxifloxacin, rifampin, and vancomycin decreased during our studies, mainly due to the decline in RT027 isolates. A decrease in moxifloxacin resistance and an increase in tetracycline resistance were found among RT027 strains isolated in the last survey. Although the proportion of RT027 isolates declined, multidrug resistance among this ribotype continues to be common.
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