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Tytuł pozycji:

Combined Ion-Trapping and Mass Balance Models To Describe the pH-Dependent Uptake and Toxicity of Acidic and Basic Pharmaceuticals in Zebrafish Embryos ( Danio rerio).

Tytuł :
Combined Ion-Trapping and Mass Balance Models To Describe the pH-Dependent Uptake and Toxicity of Acidic and Basic Pharmaceuticals in Zebrafish Embryos ( Danio rerio).
Autorzy :
Bittner L; Helmholtz Centre for Environmental Research - UFZ , Permoserstrasse 15 , 04318 Leipzig , Germany.
Klüver N; Helmholtz Centre for Environmental Research - UFZ , Permoserstrasse 15 , 04318 Leipzig , Germany.
Henneberger L; Helmholtz Centre for Environmental Research - UFZ , Permoserstrasse 15 , 04318 Leipzig , Germany.
Mühlenbrink M; Helmholtz Centre for Environmental Research - UFZ , Permoserstrasse 15 , 04318 Leipzig , Germany.
Zarfl C; Eberhard Karls University of Tübingen , Center for Applied Geoscience , Hölderlinstrasse 12 , 72074 Tübingen , Germany.
Escher BI; Helmholtz Centre for Environmental Research - UFZ , Permoserstrasse 15 , 04318 Leipzig , Germany.; Eberhard Karls University of Tübingen , Center for Applied Geoscience , Hölderlinstrasse 12 , 72074 Tübingen , Germany.
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Źródło :
Environmental science & technology [Environ Sci Technol] 2019 Jul 02; Vol. 53 (13), pp. 7877-7886. Date of Electronic Publication: 2019 Jun 24.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Washington DC : American Chemical Society
Original Publication: Easton, Pa. : American Chemical Society, c1967-
MeSH Terms :
Water Pollutants, Chemical*
Zebrafish*
Animals ; Diclofenac ; Embryo, Nonmammalian ; Hydrogen-Ion Concentration
Substance Nomenclature :
0 (Water Pollutants, Chemical)
144O8QL0L1 (Diclofenac)
Entry Date(s) :
Date Created: 20190611 Date Completed: 20191128 Latest Revision: 20191128
Update Code :
20210623
DOI :
10.1021/acs.est.9b02563
PMID :
31177773
Czasopismo naukowe
The aim of the current study was to understand and develop models to predict the pH-dependent toxicity of ionizable pharmaceuticals in embryos of the zebrafish Danio rerio. We found a higher uptake and toxicity with increasing neutral fraction of acids (diclofenac, genistein, naproxen, torasemide, and warfarin) and bases (metoprolol and propranolol). Simple mass balance models accounting for the partitioning to lipids and proteins in the zebrafish embryo were found to be suitable to predict the bioconcentration after 96 h of exposure if pH values did not differ much from the internal pH of 7.55. For other pH values, a kinetic ion-trap model for the zebrafish embryo explained the pH dependence of biouptake and toxicity. The total internal lethal concentrations killing 50% of the zebrafish embryos (ILC 50 ) were calculated from the measured BCF and LC 50 . The resulting ILC 50 were independent of external pH. Critical membrane concentrations were deduced by an internal mass balance model, and apart from diclofenac, whose specific toxicity in fish had already been established, all pharmaceuticals were confirmed to act as baseline toxicants in zebrafish.

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