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Tytuł:
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The effect of three different solutions on preventing oral mucositis in cancer patients undergoing stem cell transplantation: a non-randomized controlled trial: A Turkish study - NON-RANDOMISED TRIAL.
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Autorzy:
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Harman M; Medipol University, Stem Cell Transplantation, Istanbul.
Ovayolu N; University of Kyrenia, Faculty of Health Science, Department of Nursing, Cyprus.
Ovayolu O; Gaziantep University, Department of Nursing, Gaziantep, Turkey.
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Źródło:
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JPMA. The Journal of the Pakistan Medical Association [J Pak Med Assoc] 2019 Jun; Vol. 69 (6), pp. 811-816.
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Typ publikacji:
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Clinical Trial; Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Karachi : Pakistan Medical Association
Original Publication: Karachi.
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MeSH Terms:
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Hematopoietic Stem Cell Transplantation/*adverse effects
Neoplasms/*therapy
Pharmaceutical Solutions/*therapeutic use
Stomatitis/*drug therapy
Adolescent ; Adult ; Aged ; Benzydamine/therapeutic use ; Chlorhexidine/analogs & derivatives ; Chlorhexidine/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Morus ; Phosphates/therapeutic use ; Plant Extracts/therapeutic use ; Turkey ; Young Adult
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Contributed Indexing:
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Keywords: Stem cell transplantation, Oral mucositis, Nursing
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Substance Nomenclature:
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0 (Pharmaceutical Solutions)
0 (Phosphates)
0 (Plant Extracts)
4O21U048EF (Benzydamine)
MOR84MUD8E (chlorhexidine gluconate)
R4KO0DY52L (Chlorhexidine)
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Entry Date(s):
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Date Created: 20190614 Date Completed: 20200106 Latest Revision: 20200106
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Update Code:
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20240104
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PMID:
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31189287
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Objective: To evaluate the effect of different solutions administered to patients undergoing stem cell transplantation on oral mucositis.
Methods: The non-randomised controlled trial was conducted at a Istanbul Medipol Mega university hospital in Turkey between May 2014 and June 2016, and comprised patients undergoing stem cell transplantation. They were divided into three groups. Group 1 had patients using chlorhexidine gluconate and benzydamine hydrochloride solution. Group 2 had those using calcium and phosphate solution. Group 3 patients were using black mulberry syrup. Data was collected using a structured questionnaire and the World Health Organisation mucositis assessment scale. Assessment was done on days 7, 14 and 21. Clinical significance of oral solutions was statistically determined.
Results: Of the 83 patients, 30(36%) were in group 1, 28(34%) in group 2, and 25(30%) in group 3. On day 7, there was no significant difference in terms of grades among the groups (p>0.05). On day 14, grade 2 mucositis was seen in 2(8%) patents in group 3, 5(17.9%) in group 2 and 5(16.7%) in group 1; Grade 3 mucositis was seen in 2(6.7%) patients in group 1, but none in the other two groups. On day 21, grade 3 mucositis was present in 2(8.0%) in group 3, 2(7.1%) in group 2, and 4(13.3%) in group 1.
Conclusions: The use of black mulberry and calcium-phosphate solutions was found to be beneficial in preventing and treating oral mucositis.
