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Tytuł:
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Burden of dengue infection in India, 2017: a cross-sectional population based serosurvey.
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Autorzy:
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Murhekar MV; Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India. Electronic address: .
Kamaraj P; Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Kumar MS; Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Khan SA; ICMR-Regional Medical Research Centre, Northeast Region, Dibrugarh, India.
Allam RR; Science Health Allied Research Education India, Hyderabad, India.
Barde P; ICMR-National Institute of Research in Tribal Health, Jabalpur, India.
Dwibedi B; ICMR-Regional Medical Research Centre, Bhubaneswar, India.
Kanungo S; ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India.
Mohan U; King George's Medical University, Lucknow, India.
Mohanty SS; ICMR-Desert Medicine Research Centre, Jodhpur, India.
Roy S; ICMR-National Institute of Traditional Medicine, Belagavi, India.
Sagar V; Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Savargaonkar D; ICMR-National Institute of Malaria Research, New Delhi, India.
Tandale BV; ICMR-National Institute of Virology, Pune, India.
Topno RK; ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India.
Sapkal G; ICMR-National Institute of Virology, Pune, India.
Kumar CPG; Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Sabarinathan R; Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Kumar VS; Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Bitragunta S; Science Health Allied Research Education India, Hyderabad, India.
Grover GS; Department of Health and Family Welfare, Government of Punjab, Punjab, India.
Lakshmi PVM; Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Mishra CM; King George's Medical University, Lucknow, India.
Sadhukhan P; ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India.
Sahoo PK; ICMR-Regional Medical Research Centre, Bhubaneswar, India.
Singh SK; King George's Medical University, Lucknow, India.
Yadav CP; ICMR-National Institute of Malaria Research, New Delhi, India.
Bhagat A; ICMR-National Institute of Virology, Pune, India.
Srivastava R; ICMR-National Institute of Virology, Pune, India.
Dinesh ER; Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Karunakaran T; Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Govindhasamy C; Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Rajasekar TD; Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Jeyakumar A; Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Suresh A; Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Augustine D; Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Kumar PA; Indian Council of Medical Research (ICMR)-National Institute of Epidemiology, Chennai, India.
Kumar R; Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Dutta S; ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India.
Toteja GS; ICMR-Desert Medicine Research Centre, Jodhpur, India.
Gupta N; Epidemiology and Communicable Diseases Division, ICMR, New Delhi, India.
Mehendale SM; Epidemiology and Communicable Diseases Division, ICMR, New Delhi, India.
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Źródło:
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The Lancet. Global health [Lancet Glob Health] 2019 Aug; Vol. 7 (8), pp. e1065-e1073. Date of Electronic Publication: 2019 Jun 11.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: [England] : Elsevier Ltd. 2013-
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MeSH Terms:
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Cost of Illness*
Dengue*
Adolescent ; Adult ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Health Surveys ; Humans ; India ; Male ; Middle Aged ; Rural Population ; Urban Population ; Young Adult
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Entry Date(s):
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Date Created: 20190616 Date Completed: 20200522 Latest Revision: 20200522
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Update Code:
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20240105
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DOI:
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10.1016/S2214-109X(19)30250-5
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PMID:
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31201130
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Background: The burden of dengue virus (DENV) infection across geographical regions of India is poorly quantified. We estimated the age-specific seroprevalence, force of infection, and number of infections in India.
Methods: We did a community-based survey in 240 clusters (118 rural, 122 urban), selected from 60 districts of 15 Indian states from five geographical regions. We enumerated each cluster, randomly selected (with an Andriod application developed specifically for the survey) 25 individuals from age groups of 5-8 years, 9-17 years, and 18-45 years, and sampled a minimum of 11 individuals from each age group (all the 25 randomly selected individuals in each age group were visited in their houses and individuals who consented for the survey were included in the study). Age was the only inclusion criterion; for the purpose of enumeration, individuals residing in the household for more than 6 months were included. Sera were tested centrally by a laboratory team of scientific and technical staff for IgG antibodies against the DENV with the use of indirect ELISA. We calculated age group specific seroprevalence and constructed catalytic models to estimate force of infection.
Findings: From June 19, 2017, to April 12, 2018, we randomly selected 17 930 individuals from three age groups. Of these, blood samples were collected and tested for 12 300 individuals (5-8 years, n=4059; 9-17 years, n=4265; 18-45 years, n=3976). The overall seroprevalence of DENV infection in India was 48·7% (95% CI 43·5-54·0), increasing from 28·3% (21·5-36·2) among children aged 5-8 years to 41·0% (32·4-50·1) among children aged 9-17 years and 56·2% (49·0-63·1) among individuals aged between 18-45 years. The seroprevalence was high in the southern (76·9% [69·1-83·2]), western (62·3% [55·3-68·8]), and northern (60·3% [49·3-70·5]) regions. The estimated number of primary DENV infections with the constant force of infection model was 12 991 357 (12 825 128-13 130 258) and for the age-dependent force of infection model was 8 655 425 (7 243 630-9 545 052) among individuals aged 5-45 years from 30 Indian states in 2017.
Interpretation: The burden of dengue infection in India was heterogeneous, with evidence of high transmission in northern, western, and southern regions. The survey findings will be useful in making informed decisions about introduction of upcoming dengue vaccines in India.
Funding: Indian Council of Medical Research.
(Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.)
Comment in: Lancet Glob Health. 2019 Aug;7(8):e988-e989. (PMID: 31201129)
