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Tytuł:
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False-Negative Urine Human Chorionic Gonadotropin Testing in the Clinical Laboratory.
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Autorzy:
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Herskovits AZ; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Chen Y; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Latifi N; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Ta RM; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Kriegel G; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
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Źródło:
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Laboratory medicine [Lab Med] 2020 Jan 02; Vol. 51 (1), pp. 86-93.
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Typ publikacji:
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Evaluation Study; Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Oct. 2015- : Oxford, England: Oxford University Press
Original Publication: Philadelphia, Lippincott.
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MeSH Terms:
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Chorionic Gonadotropin/*urine
Pregnancy Tests/*standards
Adult ; Biomarkers/blood ; Biomarkers/urine ; Chorionic Gonadotropin/blood ; Clinical Laboratory Services/standards ; Clinical Laboratory Services/statistics & numerical data ; False Negative Reactions ; Female ; Humans ; Point-of-Care Systems ; Pregnancy Tests/methods
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Contributed Indexing:
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Keywords: early gestational age; human chorionic gonadotropin; point of care; pregnancy; serum hCG; urine hCG
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Substance Nomenclature:
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0 (Biomarkers)
0 (Chorionic Gonadotropin)
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Entry Date(s):
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Date Created: 20190628 Date Completed: 20200603 Latest Revision: 20200603
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Update Code:
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20240104
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DOI:
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10.1093/labmed/lmz039
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PMID:
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31245816
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Background: Human chorionic gonadotropin (hCG) assays are used to detect pregnancy, and urine point-of-care tests are frequently used to triage patients. Under certain conditions, urine tests can fail to detect pregnancy, which can have serious consequences for patient management.
Objectives: To understand the prevalence of different factors contributing to false-negative urinary hCG testing results at our institution.
Methods: Clinical data for patients with negative urine hCG results and subsequent positive or equivocal serum hCG results within a 1-year period were reviewed.
Results: Out of 9447 negative urine hCG results, 11 potential missed diagnoses were identified, with early gestational age as the most common factor, followed by β-core hook effects.
Conclusions: Although false-negative urine hCG test results are rare, understanding the commonly encountered reasons for inaccurate testing results can help clinical centers develop strategies to minimize risk for patients.
(© American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
