Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas.

Tytuł:
Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas.
Autorzy:
Grutzendler J; Yale University, Departments of Neurology and of Neuroscience, 300 George Street, Rm 8300G, New Haven, CT 06511, USA. Electronic address: .
Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center, Elmwood Avenue 601, Rochester, NY 14642, USA; Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Denmark, Blegdamsvej 3B, 2200 Copenhagen N, Denmark. Electronic address: .
Źródło:
Trends in neurosciences [Trends Neurosci] 2019 Aug; Vol. 42 (8), pp. 528-536. Date of Electronic Publication: 2019 Jun 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Język:
English
Imprint Name(s):
Publication: Barking : Elsevier Applied Science Publishing
Original Publication: Amsterdam, New York, Elsevier/North-Holland Biomedical Press.
MeSH Terms:
Brain/*blood supply
Capillaries/*physiology
Cerebrovascular Circulation/*physiology
Hemodynamics/*physiology
Neurovascular Coupling/*physiology
Animals ; Humans
References:
Circ Res. 1994 Jul;75(1):55-62. (PMID: 8013082)
Sci Adv. 2019 May 29;5(5):eaaw4466. (PMID: 31149638)
Brain Res. 2003 Feb 14;963(1-2):81-92. (PMID: 12560113)
Sci Rep. 2018 Aug 16;8(1):12272. (PMID: 30116021)
J Cereb Blood Flow Metab. 2019 Mar;39(3):411-425. (PMID: 28933255)
Neuron. 2017 Sep 27;96(1):17-42. (PMID: 28957666)
J Cereb Blood Flow Metab. 2008 May;28(5):961-72. (PMID: 18059431)
Am J Pathol. 1968 Feb;52(2):437-53. (PMID: 5635861)
Nat Neurosci. 2003 Jan;6(1):43-50. (PMID: 12469126)
Nat Neurosci. 2007 Nov;10(11):1369-76. (PMID: 17965657)
Neuron. 2015 Jul 1;87(1):95-110. (PMID: 26119027)
J Neurosci. 2014 Aug 20;34(34):11504-13. (PMID: 25143628)
J Neurophysiol. 1997 Aug;78(2):651-9. (PMID: 9307102)
Glia. 2014 Jan;62(1):78-95. (PMID: 24272704)
J Neurosci. 2016 Sep 7;36(36):9435-45. (PMID: 27605617)
Nat Med. 2009 Sep;15(9):1031-7. (PMID: 19718040)
Nature. 2018 Feb 22;554(7693):475-480. (PMID: 29443965)
Biochem J. 2013 Jan 1;449(1):143-50. (PMID: 23013433)
Nat Neurosci. 2017 Mar;20(3):406-416. (PMID: 28135240)
Cell. 2018 Aug 9;174(4):1015-1030.e16. (PMID: 30096299)
Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13081-6. (PMID: 14569029)
Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22290-5. (PMID: 21135230)
Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15741-6. (PMID: 9861040)
Nature. 2006 Oct 12;443(7112):700-4. (PMID: 17036005)
Neuron. 2018 Jul 25;99(2):362-375.e4. (PMID: 29937277)
Neuron. 2010 Nov 4;68(3):409-27. (PMID: 21040844)
J Cereb Blood Flow Metab. 2012 Dec;32(12):2135-45. (PMID: 22872230)
Nat Neurosci. 2006 Feb;9(2):260-7. (PMID: 16388306)
Nature. 2014 Apr 3;508(7494):55-60. (PMID: 24670647)
Biomed Opt Express. 2016 Sep 23;7(10):4228-4249. (PMID: 27867728)
J Appl Physiol (1985). 2006 Jan;100(1):328-35. (PMID: 16357086)
Cell Rep. 2018 Jun 26;23(13):3878-3890. (PMID: 29949771)
Nature. 2004 Sep 9;431(7005):195-9. (PMID: 15356633)
Science. 2011 Sep 30;333(6051):1888-91. (PMID: 21903779)
J Cereb Blood Flow Metab. 2013 Oct;33(10):1486-92. (PMID: 23778163)
Exp Neurol. 1967 Jun;18(2):239-52. (PMID: 6026610)
J Cereb Blood Flow Metab. 2016 Feb;36(2):451-5. (PMID: 26661200)
J Cereb Blood Flow Metab. 2015 Mar;35(3):432-42. (PMID: 25492112)
Neuron. 2016 Aug 17;91(4):851-862. (PMID: 27499087)
Sci Transl Med. 2014 Mar 5;6(226):226ra31. (PMID: 24598589)
Nat Neurosci. 2017 Jul;20(7):1023-1032. (PMID: 28504673)
Circ Res. 2017 Feb 3;120(3):449-471. (PMID: 28154097)
Nat Neurosci. 2017 May;20(5):717-726. (PMID: 28319610)
Nat Neurosci. 2016 Dec;19(12):1619-1627. (PMID: 27775719)
Sci Data. 2018 Aug 21;5:180160. (PMID: 30129931)
Cell Rep. 2018 Jan 2;22(1):8-16. (PMID: 29298435)
Grant Information:
RF1 NS110049 United States NS NINDS NIH HHS; R01 NS089734 United States NS NINDS NIH HHS; RF1 AG058257 United States AG NIA NIH HHS; R01 NS100366 United States NS NINDS NIH HHS; RF1 AG057575 United States AG NIA NIH HHS
Contributed Indexing:
Keywords: blood oxygenation; cell contractility; cerebral blood flow; energetics; microvascular occlusion; microvasculature; neurovascular coupling; pericytes; red blood cells; smooth muscle cells; stroke; transgenic mice; vascular disease; vascular resistance
Entry Date(s):
Date Created: 20190701 Date Completed: 20200921 Latest Revision: 20200921
Update Code:
20240104
PubMed Central ID:
PMC7386067
DOI:
10.1016/j.tins.2019.05.009
PMID:
31255380
Czasopismo naukowe
The precise modulation of regional cerebral blood flow during neural activation is important for matching local energetic demand and supply and clearing brain metabolites. Here we discuss advances facilitated by high-resolution optical in vivo imaging techniques that for the first time have provided direct visualization of capillary blood flow and its modulation by neural activity. We focus primarily on studies of microvascular flow, mural cell control of vessel diameter, and oxygen level-dependent changes in red blood cell deformability. We also suggest methodological standards for best practices when studying microvascular perfusion, partly motivated by recent controversies about the precise location within the microvascular tree where neurovascular coupling is initiated, and the role of mural cells in the control of vasomotility.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies