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Tytuł pozycji:

Glucose Ingestion Inhibits Endurance Exercise-Induced IL-6 Producing Macrophage Infiltration in Mice Muscle.

Tytuł:
Glucose Ingestion Inhibits Endurance Exercise-Induced IL-6 Producing Macrophage Infiltration in Mice Muscle.
Autorzy:
Tominaga T; Graduate School of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan.
Ma S; Graduate School of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan.
Saitou K; Graduate School of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan.; Neural Circuit Unit, Okinawa Institute of Science and Technology Graduate University (OIST), Okinawa 904-0495, Japan.
Suzuki K; Faculty of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan. .
Źródło:
Nutrients [Nutrients] 2019 Jun 30; Vol. 11 (7). Date of Electronic Publication: 2019 Jun 30.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI Publishing
MeSH Terms:
Physical Endurance*
Dietary Sugars/*administration & dosage
Glucose/*administration & dosage
Interleukin-6/*metabolism
Macrophages/*metabolism
Muscle, Skeletal/*metabolism
Animals ; Chemokine CCL2/genetics ; Chemokine CCL2/metabolism ; Dietary Sugars/metabolism ; Down-Regulation ; Glucose/metabolism ; Interleukin-6/genetics ; Male ; Mice, Inbred C57BL ; Time Factors
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Grant Information:
S1511017 Ministry of Education, Culture, Sports, Science and Technology of Japan
Contributed Indexing:
Keywords: endurance exercise; glucose ingestion; interleukin 6 (IL-6); macrophage; monocyte chemotactic protein (MCP)-1
Substance Nomenclature:
0 (Ccl2 protein, mouse)
0 (Chemokine CCL2)
0 (Dietary Sugars)
0 (Interleukin-6)
0 (interleukin-6, mouse)
IY9XDZ35W2 (Glucose)
Entry Date(s):
Date Created: 20190703 Date Completed: 20200107 Latest Revision: 20200225
Update Code:
20240104
PubMed Central ID:
PMC6682949
DOI:
10.3390/nu11071496
PMID:
31262006
Czasopismo naukowe
Background: Carbohydrate (CHO) supplementation during exercise attenuates exercise-induced increases in plasma Interleukin (IL)-6 concentration. However, the effects of CHO supplementation on muscle IL-6 production during endurance exercise is controversial. The purpose of this study was to investigate the effects of CHO supplementation on muscle IL-6 production during endurance exercise with a special focus on the IL-6 producing cells.
Methods: C57BL/6J mice were divided into three groups-sedentary with water ingestion group as the control (Con; n = 10), exercise with water ingestion group (Ex; n = 10), and exercise with 6% glucose ingestion group (Ex + glucose; n = 10). The Ex and Ex + glucose groups completed 3 h of treadmill running (24 m/min, 7% incline) and were sacrificed immediately after exercise.
Results: The exercise-induced increases of plasma IL-6 concentration and gastrocnemius IL-6 gene expression were attenuated by glucose ingestion. However, the increases of soleus IL-6 gene expression and gastrocnemius and soleus IL-6 protein expression were not attenuated by glucose ingestion. Furthermore, we observed that macrophages that infiltrated muscle produce IL-6 and glucose ingestion attenuated the infiltration of IL-6-producing macrophages.
Conclusion: This study revealed that infiltrating macrophages may be one type of IL-6-producing cells during endurance exercise, and the infiltration of these cells in muscle was attenuated by glucose ingestion. However, the effects of glucose ingestion on muscle IL-6 production were limited.

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