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Tytuł:
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Trabecular meshwork mesenchymal stem cell transplantation improve motor symptoms of parkinsonian rat model.
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Autorzy:
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Mostafavi H; Department of Physiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Department of Medical Nanotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Ghassemifard L; Department of Physiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Rostami A; Department of Physiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Alipour M; Department of Physiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Nadri S; Department of Medical Nanotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran; Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran; Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. Electronic address: nadri_.
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Źródło:
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Biologicals : journal of the International Association of Biological Standardization [Biologicals] 2019 Sep; Vol. 61, pp. 61-67. Date of Electronic Publication: 2019 Jun 29.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: London ; San Diego : Academic Press, c1990-
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MeSH Terms:
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Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells*/metabolism
Mesenchymal Stem Cells*/pathology
Motor Activity*
Parkinson Disease, Secondary*/metabolism
Parkinson Disease, Secondary*/pathology
Parkinson Disease, Secondary*/therapy
Trabecular Meshwork*/metabolism
Trabecular Meshwork*/pathology
Allografts ; Animals ; Disease Models, Animal ; Male ; Rats ; Rats, Wistar
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Contributed Indexing:
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Keywords: Parkinson's disease; Stem cell transplantation; Trabecular meshwork mesenchymal stem cells; Tyrosine hydroxylase
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Entry Date(s):
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Date Created: 20190703 Date Completed: 20200205 Latest Revision: 20200205
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Update Code:
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20240104
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DOI:
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10.1016/j.biologicals.2019.06.006
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PMID:
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31262640
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Stem cell transplantation is a new therapeutic strategy in the treatment of neurodegenerative disorders such as Parkinson's disease (PD). Therefore, in this study, the therapeutic effects of Trabecular Meshwork Mesenchymal Stem Cells (TM-MSCs) transplantation, as a new source of mesenchymal stem cells, were evaluated in the animal model of PD. After the development and confirmation of hemi-parkinsonian rats by administration of 6-hydroxy dopamine (6-OHDA) and apomorphine-induced rotation test, green fluorescent protein (GFP) labeled TM-MSCs (normal and induced cells) were transplanted in the striatum of rats. Next, the rotation test, rotarod test, open field, passive avoidance memory tests and immunohistochemistry for tyrosine hydroxylase (TH) were done. The results showed that the number of turns significantly decreased and the improvement of motor performance was achieved after cell transplantation. However, there was no significant difference in passive avoidance memory of animals documented by shuttle box test. The number of GFP- labeled cells expressing TH significantly is increased compared to the vehicle group. Collectively, it seems that TM-MSCs and induced TM-MSCs cell transplantation have positive effects on some aspects of the animal model of PD. Other studies may reveal the potentially positive aspects of these cells in the laboratory and clinical studies.
(Copyright © 2019 International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.)
