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Tytuł pozycji:

Photobiomodulation therapy combined with carvedilol attenuates post-infarction heart failure by suppressing excessive inflammation and oxidative stress in rats.

Tytuł:
Photobiomodulation therapy combined with carvedilol attenuates post-infarction heart failure by suppressing excessive inflammation and oxidative stress in rats.
Autorzy:
Grandinetti V; Universidade Nove de Julho, Programa de Pós-graduação em Biofotônica Aplicada as Ciências da Saúde, São Paulo, Brazil.
Carlos FP; Universidade Nove de Julho, Programa de Pós-graduação em Biofotônica Aplicada as Ciências da Saúde, São Paulo, Brazil.
Antonio EL; Universidade Federal de São Paulo, Programa de Pós-graduação em Cardiologia, São Paulo, Brazil.
de Oliveira HA; Universidade Federal de São Paulo, Programa de Pós-graduação em Cardiologia, São Paulo, Brazil.
Dos Santos LFN; Universidade Federal de São Paulo, Programa de Pós-graduação em Cardiologia, São Paulo, Brazil.
Yoshizaki A; Universidade Federal de São Paulo, Programa de Pós-graduação em Cardiologia, São Paulo, Brazil.
Mansano BSDM; Universidade Nove de Julho, Programa de Pós-graduação em Biofotônica Aplicada as Ciências da Saúde, São Paulo, Brazil.
Silva FA; Universidade Federal de São Paulo, Programa de Pós-graduação em Cardiologia, São Paulo, Brazil.; Universidade Adventista de São Paulo, São Paulo, Brazil.
Porte LA; Universidade Federal de São Paulo, Programa de Pós-graduação em Cardiologia, São Paulo, Brazil.; Universidade Adventista de São Paulo, São Paulo, Brazil.
Albuquerque-Pontes GM; Universidade Nove de Julho, Programa de Pós-graduação em Biofotônica Aplicada as Ciências da Saúde, São Paulo, Brazil.
de Carvalho PTC; Universidade Nove de Julho, Programa de Pós-graduação em Biofotônica Aplicada as Ciências da Saúde, São Paulo, Brazil.
Manchini MT; Universidade Nove de Julho, Programa de Pós-graduação em Biofotônica Aplicada as Ciências da Saúde, São Paulo, Brazil.; Universidade Federal de São Paulo, Programa de Pós-graduação em Cardiologia, São Paulo, Brazil.
Leal-Junior EC; Universidade Nove de Julho, Programa de Pós-graduação em Biofotônica Aplicada as Ciências da Saúde, São Paulo, Brazil.
Tucci PJF; Universidade Federal de São Paulo, Programa de Pós-graduação em Cardiologia, São Paulo, Brazil.
Serra AJ; Universidade Nove de Julho, Programa de Pós-graduação em Biofotônica Aplicada as Ciências da Saúde, São Paulo, Brazil. .; Universidade Federal de São Paulo, Programa de Pós-graduação em Cardiologia, São Paulo, Brazil. .
Źródło:
Scientific reports [Sci Rep] 2019 Jul 01; Vol. 9 (1), pp. 9425. Date of Electronic Publication: 2019 Jul 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:
Low-Level Light Therapy*
Oxidative Stress*/drug effects
Carvedilol/*therapeutic use
Heart Failure/*drug therapy
Animals ; Carvedilol/pharmacology ; Catalase/metabolism ; Disease Models, Animal ; Echocardiography ; Female ; Heart Failure/physiopathology ; Heart Failure/radiotherapy ; Hemodynamics/drug effects ; Inflammation/prevention & control ; Myocardial Infarction/pathology ; Myocardium/metabolism ; Myocardium/pathology ; Rats ; Rats, Wistar ; Tumor Necrosis Factor-alpha/metabolism ; Ventricular Function, Left/drug effects ; Ventricular Function, Left/physiology
References:
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Substance Nomenclature:
0 (Tumor Necrosis Factor-alpha)
0K47UL67F2 (Carvedilol)
EC 1.11.1.6 (Catalase)
Entry Date(s):
Date Created: 20190703 Date Completed: 20201015 Latest Revision: 20210110
Update Code:
20240104
PubMed Central ID:
PMC6603025
DOI:
10.1038/s41598-019-46021-1
PMID:
31263132
Czasopismo naukowe
The post-myocardial infarction heart failure (HF) still carries a huge burden since current therapy is unsuccessful to abrogate poor prognosis. Thus, new approaches are needed, and photobiomodulation therapy (PBMt) may be a way. However, it is not known whether PBMt added to a standard HF therapy provides additional improvement in cardiac remodeling in infarcted rats. This study sought to determine the combined carvedilol-drug and PBMt with low-level laser therapy value in HF. Rats with large infarcts were treated for 30 days. The functional fitness was evaluated using a motorized treadmill. Echocardiography and hemodynamic measurements were used for functional evaluations of left ventricular (LV). ELISA, Western blot and biochemical assays were used to evaluate inflammation and oxidative stress in the myocardium. Carvedilol and PBMt had a similar action in normalizing pulmonary congestion and LV end-diastolic pressure, attenuating LV dilation, and improving LV systolic function. Moreover, the application of PBMt to carvedilol-treated rats inhibited myocardial hypertrophy and improved +dP/dt of LV. PBMt alone prevented inflammation with a superior effect than carvedilol. Carvedilol and PBMt normalized 4-hydroxynonenal (a lipoperoxidation marker) levels in the myocardium. However, importantly, the addition of PBMt to carvedilol attenuated oxidized protein content and triggered a high activity of the anti-oxidant catalase enzyme. In conclusion, these data show that the use of PBMt plus carvedilol therapy results in a significant additional improvement in HF in a rat model of myocardial infarction. These beneficial effects were observed to be due, at least in part, to decreased myocardial inflammation and oxidative stress.
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