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Tytuł pozycji:

Theiler's murine encephalomyelitis virus infection of astrocytes induces the expression of chemokines which attract activated but not resting T lymphocytes.

Tytuł :
Theiler's murine encephalomyelitis virus infection of astrocytes induces the expression of chemokines which attract activated but not resting T lymphocytes.
Autorzy :
Rubio N; Instituto Cajal. C.S.I.C, Dr. Arce Avenue 37, 28002, Madrid, Spain. .
Sanz-Rodriguez F; Department of Biology, Universidad Autonoma de Madrid, Madrid, Spain.
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Źródło :
Journal of neurovirology [J Neurovirol] 2019 Dec; Vol. 25 (6), pp. 844-852. Date of Electronic Publication: 2019 Jul 05.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: 2011- : New York : Springer
Original Publication: Houndmills, Basingstoke, Hampshire ; New York, NY : Stockton Press, c1995-
MeSH Terms :
Astrocytes/*immunology
Astrocytes/*virology
Cardiovirus Infections/*immunology
Chemokine CXCL9/*immunology
Th1 Cells/*immunology
Animals ; Chemokine CXCL9/biosynthesis ; Chemotaxis, Leukocyte/immunology ; Lymphocyte Activation/immunology ; Mice ; Theilovirus
References :
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Contributed Indexing :
Keywords: Astrocytes*; CXCL9/Mig*; Chemokines*; Multiple sclerosis*; Neuroinflammation*; T lymphocytes*
Substance Nomenclature :
0 (Chemokine CXCL9)
0 (Cxcl9 protein, mouse)
Entry Date(s) :
Date Created: 20190707 Date Completed: 20201021 Latest Revision: 20201021
Update Code :
20210210
PubMed Central ID :
PMC7095026
DOI :
10.1007/s13365-019-00776-5
PMID :
31278536
Czasopismo naukowe
In this article, we studied the production of the chemokine CXCL9, also termed Mig (monokine induced by gamma interferon) by cultured SJL/J mouse astrocytes infected with the BeAn strain of Theiler's murine encephalomyelitis virus (TMEV). This picornavirus induces demyelination in the SJL/J genetically susceptible strain of mice through an immune process mediated by CD4 + Th1 T cells. Those cells were chemoattracted by chemokines inside the central nervous system (CNS) after blood-brain barrier (BBB) disruption.cRNAs from TMEV- and mock-infected astrocytes cells were hybridized to the Affymetrix murine genome U74v2 DNA microarray. Hybridization data analysis revealed the upregulation of six sequences potentially coding for Mig. We confirmed post infection Mig mRNA increase by quantitative (qPCR) and RT-PCR. The presence of Mig in the supernatants of infected astrocytes was quantified using a specific ELISA. Secreted Mig was biologically active, inducing chemoattraction of mouse activated CD4 + T lymphocytes. Conversely, attracting activity on CD3 + resting T cells that can be attributed to chemokines as CXCL12/SDF-1α could not be demonstrated in these supernatants. No overinduction of the gene coding for this chemokine was assessed by DNA hybridization either. Both recombinant IFN-γ and TNF-α inflammatory cytokines were also strong inducers of Mig in SJL/J astrocyte cultures.

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