Sesamol Inhibited Ultraviolet Radiation-Induced Hyperpigmentation and Damage in C57BL/6 Mouse Skin.

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Tytuł:: Sesamol Inhibited Ultraviolet Radiation-Induced Hyperpigmentation and Damage in C57BL/6 Mouse Skin.
Autorzy:: You YJ; Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan.
Wu PY; Department of Dermatology, China Medical University Hospital, Taichung 40402, Taiwan.; School of Medicine, China Medical University, Taichung 40402, Taiwan.
Liu YJ; Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan.; Ph.D Program for Biotechnology Industry, China Medical University, Taichung 40402, Taiwan.
Hou CW; Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsinchu 30015, Taiwan.
Wu CS; Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan.
Wen KC; Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan.
Lin CY; Department of Biotechnology, Asia University, Taichung 41354, Taiwan. .
Chiang HM; Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan. .; Ph.D Program for Biotechnology Industry, China Medical University, Taichung 40402, Taiwan. .
Źródło:: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2019 Jul 05; Vol. 8 (7). Date of Electronic Publication: 2019 Jul 05.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
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Grant Information:: MOST104-2320-B-039-006 Ministry of Science and Technology; CMU105-ASIA-08, CMU106-ASIA-20 China Medical University; MOHW104-TDU-B-212-113002 Top University Plan of the Ministry of Education, Taiwan, and Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence
Contributed Indexing:: Keywords: melanogenesis; microphthalmia-associated transcription factor; sesamol; tyrosinase; tyrosinase-related protein-1
Entry Date(s):: Date Created: 20190710 Latest Revision: 20200930
Update Code:: 20240105
PubMed Central ID:: PMC6680965
DOI:: 10.3390/antiox8070207
PMID:: 31284438
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Melanin is synthesized through a series of oxidative reactions initiated with tyrosine and catalyzed by melanogenesis-related proteins such as tyrosinase, tyrosinase-related protein-1 (TRP-1), dopachrome tautomerase (TRP-2), and microphthalmia-associated transcription factor (MITF). Our previous study demonstrated that sesamol inhibited melanin synthesis through the inhibition of the melanocortin 1 receptor (MC1R)/MITF/tyrosinase pathway in B16F10 cells. In this study, sesamol was applied to C57BL/6 mouse skin to understand its activity with respect to skin pigmentation. The results indicated that ultraviolet (UV) B-induced hyperpigmentation in the C57BL/6 mouse skin was significantly reduced by topical application of sesamol for 4 weeks. Sesamol reduced the melanin index and melanin content of the skin. In addition, sesamol elevated the brightness (L* value) of the skin. Sesamol also reduced UVB-induced hyperplasia of epidermis and collagen degradation in dermis. In immunohistochemical staining, topical application of sesamol reduced UVB-induced tyrosinase, TRP-1, TRP-2, and MITF expression in the epidermis of the skin. These results demonstrated that sesamol is a potent depigmenting agent in the animal model.

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