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Tytuł:
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Ligand-assisted synthesis and cytotoxicity of ZnSe quantum dots stabilized by N-(2-carboxyethyl)chitosans.
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Autorzy:
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Bratskaya S; Institute of Chemistry, Far Eastern Branch of RAS, 159, prosp.100-letiya Vladivostoka, Vladivostok, 690022, Russia. Electronic address: .
Sergeeva K; Institute of Automation and Control Processes, Far Eastern Branch of RAS, 5, Radio Str., Vladivostok, 690041, Russia.
Konovalova M; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, 16/10, Miklukho-Maklaya Str., Moscow, 117997, Russia.
Modin E; CIC nanoGUNE, Donostia - San Sebastian, 20018, Spain.
Svirshchevskaya E; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, 16/10, Miklukho-Maklaya Str., Moscow, 117997, Russia.
Sergeev A; Institute of Automation and Control Processes, Far Eastern Branch of RAS, 5, Radio Str., Vladivostok, 690041, Russia.
Mironenko A; Institute of Chemistry, Far Eastern Branch of RAS, 159, prosp.100-letiya Vladivostoka, Vladivostok, 690022, Russia.
Pestov A; I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of RAS, 20, S. Kovalevskoy Str., Yekaterinburg, 620990, Russia.
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Źródło:
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Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2019 Oct 01; Vol. 182, pp. 110342. Date of Electronic Publication: 2019 Jul 06.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam ; New York : Elsevier, c1993-
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MeSH Terms:
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Chitosan/*analogs & derivatives
Quantum Dots/*chemistry
Selenium Compounds/*chemical synthesis
Zinc Compounds/*chemical synthesis
Cell Line, Tumor ; Cell Survival/drug effects ; Chitosan/chemistry ; Dose-Response Relationship, Drug ; HEK293 Cells ; Hot Temperature ; Humans ; Ligands ; Luminescence ; Molecular Weight ; Organ Specificity ; Oxidation-Reduction ; Quantum Dots/toxicity ; Selenium Compounds/toxicity ; Solutions ; Water/chemistry ; Zinc Compounds/toxicity
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Contributed Indexing:
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Keywords: Carboxyalkylchitosans; Cytotoxicity; Decay time; Photoluminescence; Quantum yield; ROS; ZnSe
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Substance Nomenclature:
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0 (Ligands)
0 (N-(2-carboxyethyl)chitosan)
0 (Selenium Compounds)
0 (Solutions)
0 (Zinc Compounds)
059QF0KO0R (Water)
9012-76-4 (Chitosan)
OWX23150D5 (zinc selenide)
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Entry Date(s):
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Date Created: 20190713 Date Completed: 20200210 Latest Revision: 20200210
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Update Code:
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20240105
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DOI:
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10.1016/j.colsurfb.2019.06.071
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PMID:
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31299538
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Here we report a green synthesis of ZnSe quantum dots (QDs) in aqueous solution of polyampholyte chitosan derivative - N-(2-carboxyethyl)chitosan (CEC) with substitution degrees (DS) from 0.7 to 1.3 and molecular weight (MW) of 40 kDa and 150 kDa. We have shown that the maximum intensity of photoluminescence (PL) is exhibited by ZnSe QDs synthesized in solutions of CEC with DS 1 at Se:Zn molar ratio 1:2.5. The defect-related band was predominant in the PL spectra of ZnSe QDs obtained at room temperature; however, hydrothermal treatment at 80-150 °C during 1-2 h significantly increased contribution of exciton emission to the spectra. Cytotoxicity of ZnSe QDs was investigated by MTT assay using cancer cell lines SKOV-3; SkBr-3; PANC-1; Colon-26 and human embryonic kidney cell line HEK293. Cytotoxicity of ZnSe QDs did not depend on MW or DS of CEC but significantly depended on the cell line, being the lowest for normal human cells HEK293 and breast cancer cell line SKOV-3. The hydrothermally treated ZnSe QDs showed higher toxicity toward both normal and cancer cell lines. Since ZnSe QDs were toxic for most of the investigated cancer cell lines, they cannot be used as inert tracers for bioimaging, but can be promising for further investigation for anticancer therapy.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
