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Tytuł:
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Ethnic differences in bone mineral density among midlife women in a multi-ethnic Southeast Asian cohort.
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Autorzy:
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Thu WPP; Department of Obstetrics and Gynecology, National University Hospital, National University of Singapore, 1E Kent Ridge Road, Level 12, Singapore, 119228, Republic of Singapore.
Logan SJS; Department of Obstetrics and Gynecology, National University Hospital, National University of Singapore, 1E Kent Ridge Road, Level 12, Singapore, 119228, Republic of Singapore.
Cauley JA; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Kramer MS; Department of Obstetrics and Gynecology, National University Hospital, National University of Singapore, 1E Kent Ridge Road, Level 12, Singapore, 119228, Republic of Singapore.; Departments of Epidemiology, Biostatistics & Occupational Health and of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, H3G 1Y6, Canada.
Yong EL; Department of Obstetrics and Gynecology, National University Hospital, National University of Singapore, 1E Kent Ridge Road, Level 12, Singapore, 119228, Republic of Singapore. .
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Źródło:
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Archives of osteoporosis [Arch Osteoporos] 2019 Jul 19; Vol. 14 (1), pp. 80. Date of Electronic Publication: 2019 Jul 19.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: London : Springer, [2006]-
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MeSH Terms:
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Bone Density*
Asian People/*statistics & numerical data
Ethnicity/*statistics & numerical data
Osteoporosis/*ethnology
White People/*statistics & numerical data
Absorptiometry, Photon ; Aged ; Asia, Southeastern ; Asian People/ethnology ; Body Mass Index ; Cohort Studies ; Female ; Femur Neck/diagnostic imaging ; Femur Neck/physiopathology ; Hip Fractures/ethnology ; Humans ; India/ethnology ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/physiopathology ; Malaysia/ethnology ; Middle Aged ; Risk Factors ; Singapore/ethnology ; White People/ethnology
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Contributed Indexing:
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Keywords: Asian; Bone mineral density; Ethnic differences; Osteoporosis; Singapore
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Entry Date(s):
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Date Created: 20190721 Date Completed: 20200501 Latest Revision: 20221207
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Update Code:
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20240105
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DOI:
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10.1007/s11657-019-0631-0
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PMID:
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31324992
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Chinese Singaporean middle-aged women have significantly lower femoral neck bone mineral density and higher lumbar spine bone mineral density than Malays and Indians, after adjustment for age, body mass index, and height.
Purpose: Information regarding mediators of differences in bone mineral density (BMD) among Asian ethnicities are limited. Since the majority of hip fractures are predicted to be from Asia, differences in BMD in Asian ethnicities require further exploration. We compared BMD among the Chinese, Malay, or Indian ethnicities in Singapore, aiming to identify potential mediators for the observed differences.
Methods: BMD of 1201 women aged 45-69 years was measured by dual-energy X-ray absorptiometry. We examined the associations between ethnicity and BMD at both sites, before and after adjusting for potential mediators measured using standardized questionnaires and validated performance tests.
Results: Chinese women had significantly lower femoral neck BMD than Malay and Indian women. Of the more than 20 variables examined, age, body mass index, and height accounted for almost all the observed ethnic differences in femoral neck BMD between Chinese and Malays. However, Indian women still retained 0.047 g/cm 2 (95% CI, 0.024, 0.071) higher femoral neck BMD after adjustment, suggesting that additional factors may contribute to the increased BMD in Indians. Although no crude ethnic differences in lumbar spine BMD were observed, adjusted regression model unmasked ethnic differences, wherein Chinese women had 0.061(95% CI, - 0.095, 0.026) and 0.065 (95% CI, - 0.091, 0.038) g/cm 2 higher lumbar spine BMD compared to Malay and Indian women, respectively.
Conclusion: BMD in middle-aged Asian women differ by ethnicity and site. Particular attention should be paid to underweight women of Chinese ethnic origin, who may be at highest risk of osteoporosis at the femoral neck and hence hip fractures.
