Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model.

Tytuł:: Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model.
Autorzy:: Matsukura T; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.; Department of Life Sciences, Toyo University, Gunma, Japan.
Inaba C; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Weygant EA; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Kitamura D; Department of Life Sciences, Toyo University, Gunma, Japan.
Janknecht R; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Matsumoto H; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.; Clinical Proteomics and Gene Therapy Laboratory, Kurume University Graduate School of Medicine, Kurume, Japan.
Hyink DP; Department of Medicine, Baylor College of Medicine, Houston, Texas.
Kashiwada S; Department of Life Sciences, Toyo University, Gunma, Japan.
Obara T; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Źródło:: Physiological reports [Physiol Rep] 2019 Jul; Vol. 7 (14), pp. e14172.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013-
MeSH Terms:: Cadmium Poisoning/*therapy
Extracellular Vesicles/*transplantation
Mesenchymal Stem Cell Transplantation/*methods
Animals ; Bone Marrow Cells/metabolism ; Cadmium Poisoning/metabolism ; Cells, Cultured ; Extracellular Vesicles/metabolism ; Humans ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/pathology ; Mesenchymal Stem Cells/metabolism ; Mitochondria/metabolism ; Mitochondria/pathology ; Oryzias ; Podocytes/metabolism ; Podocytes/pathology
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Contributed Indexing:: Keywords: Bone; cadmium; chronic kidney disease; extracellular vesicles; medaka; mesenchymal stem cells
Entry Date(s):: Date Created: 20190721 Date Completed: 20200727 Latest Revision: 20210110
Update Code:: 20240105
PubMed Central ID:: PMC6642321
DOI:: 10.14814/phy2.14172
PMID:: 31325249
: Czasopismo naukowe

Pełny tekst

Treatment modalities for kidney disease caused by long-term exposure to heavy metals, such as cadmium (Cd), are limited. Often, chronic, long-term environmental exposure to heavy metal is not recognized in the early stages; therefore, chelation therapy is not an effective option. Extracellular vesicles (EVs) derived from stem cells have been demonstrated to reduce disease pathology in both acute and chronic kidney disease models. To test the ability of EVs derived from human bone marrow mesenchymal stem cells (hBM-MSCs) to treat Cd damage, we generated a Cd-exposed medaka model. This model develops heavy metal-induced cell damage in various organs and tissues, and shows decreased overall survival. Intravenous injection of highly purified EVs from hBM-MSCs repaired the damage to apical and basolateral membranes and mitochondria of kidney proximal tubules, glomerular podocytes, bone deformation, and improved survival. Our system also serves as a model with which to study age- and sex-dependent cell injuries of organs caused by various agents and diseases. The beneficial effects of EVs on the tissue repair process, as shown in our novel Cd-exposed medaka model, may open new broad avenues for interventional strategies.
(© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.)

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