Identification of hepatitis B virus genotype A/E recombinants in Ghana.

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Tytuł:: Identification of hepatitis B virus genotype A/E recombinants in Ghana.
Autorzy:: Boyce CL; Division of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Willis S; Division of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Archampong TNA; Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.; Korle-Bu Teaching Hospital, Accra, Ghana.
Lartey M; Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.; Korle-Bu Teaching Hospital, Accra, Ghana.
Sagoe KW; Department of Medical Microbiology, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana.
Obo-Akwa A; Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.
Kenu E; Korle-Bu Teaching Hospital, Accra, Ghana.; School of Public Health, College of Health Sciences, University of Ghana, Accra, Ghana.
Kwara A; Division of Infectious Diseases and Global Medicine, University of Florida, Gainesville, FL, USA.
Blackard JT; Division of Digestive Disease, University of Cincinnati College of Medicine, Cincinnati, OH, USA. .
Źródło:: Virus genes [Virus Genes] 2019 Oct; Vol. 55 (5), pp. 707-712. Date of Electronic Publication: 2019 Jul 25.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Boston Ma : Kluwer Academic
Original Publication: Boston, USA : M. Nijhoff, 1987-
MeSH Terms:: Genotype*
Recombination, Genetic*
Hepatitis B/*virology
Hepatitis B virus/*classification
Hepatitis B virus/*genetics
Adult ; Cluster Analysis ; Female ; Ghana ; Hepatitis B virus/isolation & purification ; Humans ; Male ; Middle Aged ; Phylogeny ; Whole Genome Sequencing
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Grant Information:: P30 DK078392 United States DK NIDDK NIH HHS; D43TW010055 United States TW FIC NIH HHS; P30AI042853 Lifespan/Tufts/Brown CFAR; D43 TW010055 United States TW FIC NIH HHS; D43 TW000237 United States TW FIC NIH HHS; P30-ES006096 National Institute of Environmental Health Science; D43TW000237 Brown/Tufts AIDS International Training and Research Program; P30 ES006096 United States ES NIEHS NIH HHS; AEG-A-00-05-00007 USAID/HED; P30 AI042853 United States AI NIAID NIH HHS
Contributed Indexing:: Keywords: Africa; Genotype; Ghana; Hepatitis B virus; Recombinant/recombination
Entry Date(s):: Date Created: 20190727 Date Completed: 20200110 Latest Revision: 20201001
Update Code:: 20240105
PubMed Central ID:: PMC6750976
DOI:: 10.1007/s11262-019-01690-y
PMID:: 31346975
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Hepatitis B virus (HBV) exhibits a high degree of heterogeneity with at least 10 genotypes (A-J) identified to date. Intergenotypic recombination is relatively common. Previously, we investigated HBV drug resistance in HIV/HBV co-infected individuals in Ghana. After identifying multiple circulating genotypes and a novel D/E recombinant, we sought to determine if additional individuals were also infected with recombinant HBV. Partial genome sequences from three individuals were initially identified as genotype A4. Full-length HBV genomes were obtained using rolling circle amplification followed by PCR and shown to cluster with known A/E recombinant viruses. Similar recombination breakpoints were observed in these three individuals suggesting local spread of this novel recombinant HBV in Ghana.

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